Ethanone,2-[(2R,6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl]-1-phenyl- cas no:90-69-7

NameEthanone,2-[(2R,6S)-6-[(2S)-2-hydroxy-2-phenylethyl]-1-methyl-2-piperidinyl]-1-phenyl-
CAS90-69-7
SynonymsEthanone,2-[6-(2-hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl]-1-phenyl-, [2R-[2a,6a(S*)]]-; Lobeline (8CI); a-Lobeline (7CI); (-)-Lobeline; (-)-a-Lobeline; 2-[6-(b-Hydroxyphenethyl)-1-methyl-2-piperidyl]acetophenone;8,10-Diphenyllobelionol; Inflatine; L-Lobeline; Lobelin; Lobnico; NIH 11034;l-Lobeline
EINECS(EC#)202-012-3
Molecular FormulaC22H27 N O2
Molecular Weight337.46

refractive index1.562

Hazardclass6.1(b)

Safety

Poison by intraperitoneal and intravenous routes. Causes stimulation which leads to convulsions in severe cases. Nausea and vomiting are frequent. When heated to decomposition it emits toxic fumes of NO_x.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	43500ug/kg (43.5mg/kg)		Strahlentherapie. Vol. 127, Pg. 245, 1965.
mouse	LD50	intravenous	6300ug/kg (6.3mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 103, Pg. 146, 1955.
mouse	LDLo	subcutaneous	100mg/kg (100mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 132, Pg. 63, 1928.
rabbit	LD50	subcutaneous	35mg/kg (35mg/kg)		Farmakologiya i Toksikologiya Vol. 4(1), Pg. 34, 1941.
rabbit	LDLo	intravenous	10mg/kg (10mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Journal of Pharmacology and Experimental Therapeutics. Vol. 31, Pg. 43, 1927.
rat	LDLo	subcutaneous	80mg/kg (80mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 132, Pg. 63, 1928.