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Resins, podophyllum cas no:9000-55-9

Synonyms: Podophyllin;Podophyllum (resin); Podophyllum (the resin); Podophyllum, resin; Podophyllum,resins of; Mayapple, resin; Resins Podophyllum

Identification
NameResins, podophyllum
CAS9000-55-9
SynonymsPodophyllin;Podophyllum (resin); Podophyllum (the resin); Podophyllum, resin; Podophyllum,resins of; Mayapple, resin; Resins Podophyllum
EINECS(EC#)232-546-2
Molecular FormulaC88H92O34
Molecular Weight1693.65168
Chemical Properties
Appearancelight yellow to brown powder
storage temp2-8°C
Safety Data

Hazard T+
Risk R61
Safety

Poison by ingestion, subcutaneous, and intraperitoneal routes. An irritant to skin, eyes, and mucous membranes. Questionable carcinogen with experimental neoplastigenic data. An experimental teratogen. Other experimental reproductive effects. Combustible when exposed to heat or flames. When heated to decomposition it emits acrid smoke and irritating fumes. 
Hazard Codes:
VeryT+
Risk Statements:
R61:May cause harm to the unborn child. 
R26/27/28:Very toxic by inhalation, in contact with skin and if swallowed. 
R34:Causes burns.
Safety Statements:
S53:Avoid exposure - obtain special instructions before use. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S27:Take off immediately all contaminated clothing. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: TP8925000


Toxicity
Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo unreported 120mg/kg (120mg/kg)   "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
man LDLo oral 157mg/kg (157mg/kg) behavioral: somnolence (general depressed activity) gastrointestinal: "hypermotility, diarrhea" gastrointestinal: nausea or vomiting Southern Medical Journal. Vol. 75, Pg. 1269, 1982.
man TDLo oral 1333mg/kg (1333mg/kg) behavioral: coma Human Toxicology. Vol. 1, Pg. 373, 1982.
mouse LD50 oral 68mg/kg (68mg/kg) behavioral: excitement behavioral: muscle weakness lungs, thorax, or respiration: dyspnea Proceedings of the Society for Experimental Biology and Medicine. Vol. 77, Pg. 269, 1951.
mouse LD50 subcutaneous 58mg/kg (58mg/kg) behavioral: excitement lungs, thorax, or respiration: dyspnea behavioral: muscle weakness Proceedings of the Society for Experimental Biology and Medicine. Vol. 77, Pg. 269, 1951.
rat LD50 intraperitoneal 15mg/kg (15mg/kg)   Proceedings of the Society for Experimental Biology and Medicine. Vol. 113, Pg. 124, 1963.
rat LD50 parenteral 25mg/kg (25mg/kg) peripheral nerve and sensation: flaccid paralysis without anesthesia (usually neuromuscular blockage) behavioral: muscle contraction or spasticity) Archives Internationales de Pharmacodynamie et de Therapie. Vol. 84, Pg. 68, 1950.
rat LD50 subcutaneous 18mg/kg (18mg/kg) behavioral: excitement behavioral: muscle weakness lungs, thorax, or respiration: dyspnea Proceedings of the Society for Experimental Biology and Medicine. Vol. 77, Pg. 269, 1951.
women LDLo oral 6mg/kg (6mg/kg) behavioral: ataxia lungs, thorax, or respiration: respiratory stimulation gastrointestinal: nausea or vomiting "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 482, 1969.
women TDLo oral 80mg/kg (80mg/kg) sense organs and special senses: conjunctive irritation: eye vascular: bp lowering not characterized in autonomic section Clinical Toxicology. Vol. 18, Pg. 973, 1981.

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