9000-55-9|Resins, podophyllumProducts Supply - Chemical intermediates Network

Resins, podophyllum cas no:9000-55-9

Synonyms: Podophyllin;Podophyllum (resin); Podophyllum (the resin); Podophyllum, resin; Podophyllum,resins of; Mayapple, resin; Resins Podophyllum

Identification

NameResins, podophyllum
CAS9000-55-9
SynonymsPodophyllin;Podophyllum (resin); Podophyllum (the resin); Podophyllum, resin; Podophyllum,resins of; Mayapple, resin; Resins Podophyllum
EINECS(EC#)232-546-2
Molecular FormulaC88H92O34
Molecular Weight1693.65168

Chemical Properties

Appearancelight yellow to brown powder
storage temp2-8°C

Safety Data

Hazard T+
Risk R61
Safety

Poison by ingestion, subcutaneous, and intraperitoneal routes. An irritant to skin, eyes, and mucous membranes. Questionable carcinogen with experimental neoplastigenic data. An experimental teratogen. Other experimental reproductive effects. Combustible when exposed to heat or flames. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes:
Very T+
Risk Statements:
R61:May cause harm to the unborn child.
R26/27/28:Very toxic by inhalation, in contact with skin and if swallowed.
R34:Causes burns.
Safety Statements:
S53:Avoid exposure - obtain special instructions before use.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S27:Take off immediately all contaminated clothing.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: TP8925000

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LDLo	unreported	120mg/kg (120mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
man	LDLo	oral	157mg/kg (157mg/kg)	behavioral: somnolence (general depressed activity) gastrointestinal: "hypermotility, diarrhea" gastrointestinal: nausea or vomiting	Southern Medical Journal. Vol. 75, Pg. 1269, 1982.
man	TDLo	oral	1333mg/kg (1333mg/kg)	behavioral: coma	Human Toxicology. Vol. 1, Pg. 373, 1982.
mouse	LD50	oral	68mg/kg (68mg/kg)	behavioral: excitement behavioral: muscle weakness lungs, thorax, or respiration: dyspnea	Proceedings of the Society for Experimental Biology and Medicine. Vol. 77, Pg. 269, 1951.
mouse	LD50	subcutaneous	58mg/kg (58mg/kg)	behavioral: excitement lungs, thorax, or respiration: dyspnea behavioral: muscle weakness	Proceedings of the Society for Experimental Biology and Medicine. Vol. 77, Pg. 269, 1951.
rat	LD50	intraperitoneal	15mg/kg (15mg/kg)		Proceedings of the Society for Experimental Biology and Medicine. Vol. 113, Pg. 124, 1963.
rat	LD50	parenteral	25mg/kg (25mg/kg)	peripheral nerve and sensation: flaccid paralysis without anesthesia (usually neuromuscular blockage) behavioral: muscle contraction or spasticity)	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 84, Pg. 68, 1950.
rat	LD50	subcutaneous	18mg/kg (18mg/kg)	behavioral: excitement behavioral: muscle weakness lungs, thorax, or respiration: dyspnea	Proceedings of the Society for Experimental Biology and Medicine. Vol. 77, Pg. 269, 1951.
women	LDLo	oral	6mg/kg (6mg/kg)	behavioral: ataxia lungs, thorax, or respiration: respiratory stimulation gastrointestinal: nausea or vomiting	"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 482, 1969.
women	TDLo	oral	80mg/kg (80mg/kg)	sense organs and special senses: conjunctive irritation: eye vascular: bp lowering not characterized in autonomic section	Clinical Toxicology. Vol. 18, Pg. 973, 1981.

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Resins, podophyllum cas no:9000-55-9

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