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Heparin cas no:9005-49-6

Synonyms: Ardeparin;AVE 5026;Centaxarin;CY 222;CY 216;Bemiparin;Arteven;Multiparin;Nadroparin;Nadroparine;Novoheparin;OP 386;OP 622;Octaparin;Pabyrn;Parnaparin;Reviparin;Subeparin;Tinzaparin;Vetren;a-Heparin;LipoHep Forte;KB 101;Heparin sulfate;Hapacarin;H 5284;Fraxiparin;Fragmin A;F 202;Clivarine;Clevarin;Mono-embolex;

Identification
NameHeparin
CAS9005-49-6
SynonymsArdeparin;AVE 5026;Centaxarin;CY 222;CY 216;Bemiparin;Arteven;Multiparin;Nadroparin;Nadroparine;Novoheparin;OP 386;OP 622;Octaparin;Pabyrn;Parnaparin;Reviparin;Subeparin;Tinzaparin;Vetren;a-Heparin;LipoHep Forte;KB 101;Heparin sulfate;Hapacarin;H 5284;Fraxiparin;Fragmin A;F 202;Clivarine;Clevarin;Mono-embolex;
EINECS(EC#)232-681-7
Molecular FormulaUnspecified
Molecular Weight402.65294
Chemical Properties
Appearancewhite or category of white crystalline powder.
refractive index1.711
storage tempKeep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Safety Data

Hazard May cause internal bleeding.
Safety

Safety Statements of Heparin (CAS NO.9005-49-6): 24/25 
S24/25: Avoid contact with skin and eyes.
WGK Germany: 2
RTECS: MI0850000
F: 3-10
Moderately toxic by ingestion, intraperitoneal, and intravenous routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also HEPARIN SODIUM


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo intravenous 3536units/kg/ (3536units/kg)   Southern Medical Journal. Vol. 80, Pg. 1450, 1987.
man TDLo subcutaneous 1857units/kg/ (1857units/kg) CARDIAC: OTHER CHANGES Southern Medical Journal. Vol. 80, Pg. 1450, 1987.
mouse LD50 intraperitoneal 1900mg/kg (1900mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 60, Pg. 507, 1964.
mouse LD50 intravenous 500mg/kg (500mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Arzneimittel-Forschung. Drug Research. Vol. 36, Pg. 1366, 1986.
mouse LD50 subcutaneous 500mg/kg (500mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS
Arzneimittel-Forschung. Drug Research. Vol. 36, Pg. 1366, 1986.
rat LD50 oral 1950mg/kg (1950mg/kg)   German Offenlegungsschrift Patent Document. Vol. #2636091,
rat LDLo intraperitoneal 420mg/kg (420mg/kg)   Toxicology and Applied Pharmacology. Vol. 1, Pg. 156, 1959.
women TDLo subcutaneous 30uL/kg/5D-I (0.03mL/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" British Journal of Haematology. Vol. 82, Pg. 620, 1992.
women TDLo subcutaneous 48mg/kg/20D-I (48mg/kg) BLOOD: HEMORRHAGE

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Australian and New Zealand Journal of Medicine. Vol. 28, Pg. 59, 1998.
women TDLo subcutaneous 1000units/kg/ (1000units/kg)   Southern Medical Journal. Vol. 80, Pg. 1450, 1987.

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