Sorbitan,mono-(9Z)-9-octadecenoate, poly(oxy-1,2-ethanediyl) derivs. cas no:9005-65-6

NameSorbitan,mono-(9Z)-9-octadecenoate, poly(oxy-1,2-ethanediyl) derivs.
CAS9005-65-6
SynonymsSorbitan,mono-9-octadecenoate, poly(oxy-1,2-ethanediyl) derivs., (Z)-; Sorbitan,monooleate, polyoxyethylene derivs. (8CI); Glycols, polyethylene, ether withsorbitan monooleate (8CI); Alkamuls PSMO 20; Alkamuls T 80; Atlox 1087; Atlox8916TF; Canarcel TW 80; Capmul POE-O; Cemerol T 80; Cemesol TW 1020; Crill 10;Crill 11; Crill S 10; Crillet 4; Crillet 4 HP; Crillet 4 Super; Crillet 41;Crodalan AWS; Disponil SMO 120; Disponil SMO 120 Spez; Durfax 80; E 433; E 433(polyglycol); Ecoteric 20; Ecoteric T 80; Emalex ET 8020; Emasol O 105R; Emsorb6900; Emulson 10OM; Ethoxylated sorbitan monooleate; Ethsorbox O 20; Ethylan GE08; Ethylene oxide-sorbitan monooleate polymer; Eumulgin SMO 20; Flo Mo SMO 20;Glycosperse O 20; Glycosperse O 5; Hexaethylene glycol sorbitan monooleate;Hodag SVO 9; Ionet T 80; Ionet T 80C; Ionet T 80V; Ionet-T 80PA; Lamesorb SMO20; Liposorb O 20VBE; MO 55F; Montanox 80; Montanox 81VG; Montanox DF 80;Myvatex MSPS; Nikkol TO 10; Nikkol TO 106; Nikkol TO 10M; Nikkol TO 10MV;Nikkol TO 10V; Nissan Nonion OT 220; Nissan Nonion OT 221; Nofable ESO 9920;Nonio-light 0-30; Nonio-light SPO 1; Nonion OT 220; Nonion OT 221; Olothorb;PEG sorbitan monooleate; PEO(20) sorbitan monooleate; POE sorbitan monooleate;Polisorbac 60; Polyethoxylated sorbitan monooleate; Polyethylene glycolsorbitan ether monooleate; Polyethylene glycol sorbitan monooleate;Polyoxyethylated sorbitan monooleate; Polyoxyethylene monosorbitan monooleate;Polyoxyethylene sorbitan monooleate; Polyoxyethylenesorbitan oleate; Polysorban80; Polysorbate 80; Polysorbate 81; Radiasurf 7157; Rheodol Super TW-O 120;Rheodol TQ-O 106; Rheodol TW 0120V; Rheodol TW-O 106; Rheodol TW-O 106V;Rheodol TW-O 120; Rheodol TW-O 120V; Romulgin O; SVO 9; Setrolene O; Silvan T80; Simugel EG; Sorbax PMO 20; Sorbimacrogol oleate; Sorbimacrogol oleate 100;Sorbimacrogol oleate 300; Sorbital O 20; Sorbitan monooleate ethylene oxideadduct; Sorbitan monooleate polyethylene glycol ether; Sorbitan monooleatepolyoxyethylene ether;
EINECS(EC#)500-019-9
Molecular FormulaC24H44O6
Molecular Weight428.600006103516

Appearancepale yellow oily liquid
refractive index1.471-1.473
storage tempStore at RT.

Hazard UN NO.
Risk 22-36/37/38-37/38-41
Safety Moderately toxic by intravenous route. Mildly toxic by ingestion. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Human mutation data reported. An eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes.
HS Code 34021300

CHEMICAL IDENTIFICATION

RTECS NUMBER :

WG2932500

CHEMICAL NAME :

Sorbitan, monooleate polyoxyethylene deriv.

CAS REGISTRY NUMBER :

9005-65-6

LAST UPDATED :

199710

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Standard Draize test

ROUTE OF EXPOSURE :

Administration into the eye

SPECIES OBSERVED :

Rodent - rabbit

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

34500 uL/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

6804 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1790 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

25 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

7600 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Rodent - mouse

DOSE/DURATION :

4500 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

500 mg/kg

TOXIC EFFECTS :

Behavioral - altered sleep time (including change in righting reflex) Cardiac - other changes

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Mammal - cat

DOSE/DURATION :

500 mg/kg

TOXIC EFFECTS :

Behavioral - altered sleep time (including change in righting reflex) Cardiac - other changes

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Mammal - species unspecified

DOSE/DURATION :

25 gm/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :

Intravenous

SPECIES OBSERVED :

Mammal - species unspecified

DOSE/DURATION :

5800 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

42 gm/kg/2W-C

TOXIC EFFECTS :

Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

2163 gm/kg/2Y-C

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria Endocrine - adrenal cortex tumors

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

10 gm/kg/27W-I

TOXIC EFFECTS :

Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

635 gm/kg

SEX/DURATION :

multigenerations

TOXIC EFFECTS :

Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive) Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

1270 gm/kg

SEX/DURATION :

female 84 day(s) pre-mating - 21 day(s) post-birth

TOXIC EFFECTS :

Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

DOSE :

80 uL/kg

SEX/DURATION :

lactating female 4 day(s) post-birth

TOXIC EFFECTS :

Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Maternal Effects - menstrual cycle changes or disorders Reproductive - Effects on Newborn - physical

MUTATION DATA

TYPE OF TEST :

DNA inhibition

TEST SYSTEM :

Rodent - mouse Cells - not otherwise specified

DOSE/DURATION :

20 ppm

REFERENCE :

ENPBBC Environmental Physiology and Biochemistry. (Copenhagen, Denmark) V.2-5, 1972-75. Discontinued. Volume(issue)/page/year: 5,84,1975 *** REVIEWS *** TOXICOLOGY REVIEW ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974- Volume(issue)/page/year: 32,245,1974 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80605 No. of Facilities: 1388 (estimated) No. of Industries: 18 No. of Occupations: 32 No. of Employees: 24861 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X8582 No. of Facilities: 6365 (estimated) No. of Industries: 38 No. of Occupations: 70 No. of Employees: 162120 (estimated) No. of Female Employees: 112349 (estimated)