90357-06-5|BicalutamideProducts Supply - Chemical intermediates Network

Bicalutamide cas no:90357-06-5

Synonyms: (2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorophenyl)sulfonyl-2-hydroxy-2-methyl-propanamide;Casodex;Propanamide, N-(4-cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl)sulfonyl)-2-hydroxy-2-methyl-, (+-)-;Bicalutamide (JAN/USP);Casodex (TN);(±)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-methyl-[(4- fluorophenyl) sulfonyl]-2-hydroxy- 2-methyl propanamide;N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-fluorophenylsulfonyl)-2-hydroxy-2-methylpropanamide;Bicalutamide [USAN:BAN:INN];ICI 176334;Propanamide,N-[4-cyano-3-(trifluoromethyl)- phenyl]-3-[(4-fluorophenyl)sulfonyl]-2- hydroxy-2-methyl-;

Identification

NameBicalutamide
CAS90357-06-5
Synonyms(2S)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorophenyl)sulfonyl-2-hydroxy-2-methyl-propanamide;Casodex;Propanamide, N-(4-cyano-3-(trifluoromethyl)phenyl)-3-((4-fluorophenyl)sulfonyl)-2-hydroxy-2-methyl-, (+-)-;Bicalutamide (JAN/USP);Casodex (TN);(±)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-methyl-[(4- fluorophenyl) sulfonyl]-2-hydroxy- 2-methyl propanamide;N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-fluorophenylsulfonyl)-2-hydroxy-2-methylpropanamide;Bicalutamide [USAN:BAN:INN];ICI 176334;Propanamide,N-[4-cyano-3-(trifluoromethyl)- phenyl]-3-[(4-fluorophenyl)sulfonyl]-2- hydroxy-2-methyl-;
Molecular FormulaC₁₈H₁₄F₄N₂O₄S
Molecular Weight430.373373

Chemical Properties

Appearanceoff-white crystalline solid
refractive index1.577
storage tempStore in original container in a cool dark place.

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass9

Safety Data

Hazard Xi: Irritant;
Risk R36/37/38
Safety

?Bicalutamide (CAS NO.90357-06-5) is?contraindicated ,females and children? must not be given to any patient who has shown a hypersensitivity reaction to its use.?
Hazard Codes:? Irritant Xi
Risk Statements: 36/37/38?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36
?S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.
RIDADR: 3077
HazardClass: 9
PackingGroup: III

HS Code 29242995

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD	oral	> 2gm/kg (2000mg/kg)	?	Journal of Toxicological Sciences. Vol. 22, Pg. 75, 1997.
mouse	LD	oral	> 2gm/kg (2000mg/kg)	?	Journal of Toxicological Sciences. Vol. 22, Pg. 75, 1997.
mouse	LD50	intraperitoneal	> 2gm/kg (2000mg/kg)	?	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 42, Pg. 197, 2000.
rabbit	LD50	oral	> 200mg/kg (200mg/kg)	?	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 42, Pg. 197, 2000.
rat	LD	oral	> 2gm/kg (2000mg/kg)	?	Journal of Toxicological Sciences. Vol. 22, Pg. 75, 1997.
rat	LD50	intraperitoneal	> 2gm/kg (2000mg/kg)	?	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 42, Pg. 197, 2000.

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Bicalutamide cas no:90357-06-5

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