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Sodium Hyaluronate cas no:9067-32-7

Synonyms: Hyaluronic acid sodium salt; Chlamyhyaluronic acid sodium salt; HA Sodium

Identification
NameSodium Hyaluronate
CAS9067-32-7
SynonymsHyaluronic acid sodium salt; Chlamyhyaluronic acid sodium salt; HA Sodium
EINECS(EC#)232-678-0
Molecular FormulaC28H44N2O23?Na
Molecular Weight799.6366
Chemical Properties
Appearancesolid
storage temp?20°C
Safety Data

Hazard Xi: Irritant;
Risk 36/37/38
Safety

Hazard Codes:?BiohazardB,IrritantXi
Risk Statements: 36/37/38?
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24/25-36/37/39-27-26?
S22:Do not breathe dust.?
S24/25:Avoid contact with skin and eyes.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.?
S27:Take off immediately all contaminated clothing.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
RTECS: MT7250000
F: 3-10
Moderately toxic by intraperitoneal route. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of Na2O.


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 subcutaneous > 50mg/kg (50mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 19(Suppl,
mouse LD50 intraperitoneal 1500mg/kg (1500mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Oyo Yakuri. Pharmacometrics. Vol. 28, Pg. 1013, 1984.
mouse LD50 oral > 2400mg/kg (2400mg/kg) ? Drugs in Japan Vol. -, Pg. 849, 1990.
mouse LD50 subcutaneous > 4gm/kg (4000mg/kg) BEHAVIORAL: ATAXIA Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984.
rabbit LD50 intraperitoneal 1820mg/kg (1820mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BLOOD: NORMOCYTIC ANEMIA
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984.
rabbit LD50 oral > 1gm/kg (1000mg/kg) ? Drugs in Japan Vol. -, Pg. 849, 1990.
rabbit LD50 subcutaneous > 2gm/kg (2000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984.
rat LD50 intraperitoneal 1770mg/kg (1770mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BLOOD: NORMOCYTIC ANEMIA
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984.
rat LD50 oral > 800mg/kg (800mg/kg) ? Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984.
rat LD50 subcutaneous > 4gm/kg (4000mg/kg) BEHAVIORAL: ATAXIA Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 12, Pg. 5369, 1984.

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Qufu Guanglong Biochemical Production Co.,Ltd.
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Shanghai Leasun Chemical Co., Ltd.
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SHANGHAI TRUSTIN CHEMICAL CO.,LTD
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Shangyu Zhongchang Chemical Co.,LTD.
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Pharmasi Chemicals Co.,Ltd
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Address: Room 205, Renlesancun50-29,songjiang,shanghai,China
connect chemical co.,ltd
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Yantai Dongcheng Biochemical Co., Ltd.
Tel:+86-(535)-637-3853, 637-8569, 637-0505
Address: No.7 Changbaishan Road, Yantai Development Zone, ShanDong 264006,
Shanghai Winhong Biology Technology Co., Ltd.
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China Chem Source (Hk) Co., Ltd.
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Jiangyin Healthway International Trade Co., Ltd
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Tianjin Norland Biotech Co.,Ltd.
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Connect Chemicals GmbH
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Address: Zapp-Platz 1, Ratingen D-40880,
Lipo Chemicals Inc.
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Address: 207 Nineteenth Avenue, Paterson, New Jersey 07504,
San Esters Corp.
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Address: 55 East 59th Street, 19th Flr, New York, New York 10022,
Jiagen Biotechnologies Inc.
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