1-Piperazineethanol,4-[3-(5H-dibenz[b,f]azepin-5-yl)propyl]-, hydrochloride (1:2) cas no:909-39-7

Name1-Piperazineethanol,4-[3-(5H-dibenz[b,f]azepin-5-yl)propyl]-, hydrochloride (1:2)
CAS909-39-7
Synonyms1-Piperazineethanol,4-[3-(5H-dibenz[b,f]azepin-5-yl)propyl]-, dihydrochloride (7CI,8CI,9CI);5H-Dibenz[b,f]azepine, 1-piperazineethanol deriv.;4-[3-(5H-Dibenz[b,f]azepin-5-yl)propyl]-1-piperazineethanol dihydrochloride;5-[g-(b-Hydroxyethylpiperazino)propyl]-5H-dibenzo[b,f]azepinedihydrochloride; Dinsidon; G 33040; Insidon; Insidone; Nisidana; Opipramolhydrochloride; Pramolan
EINECS(EC#)213-000-2
Molecular FormulaC23H29 N3 O . 2 Cl H
Molecular Weight436.47

Hazard Xn: Harmful;N: Dangerous for the environment;
Risk R22
Safety

A poison by intraperitoneal, intravenous, and subcutaneous routes. Moderately toxic by ingestion. Human systemic effects by ingestion: somnolence. When heated to decomposition it emits very toxic fumes of NO_x and HCl.

Hazard CodesXn,N
Risk Statements 22-50/53
R22:Harmful if swallowed. 
R50/53: Insidon dihydrochloride (CAS NO.909-39-7) is very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Safety Statements 60-61
S60:This material and its container must be disposed of as hazardous waste. 
S61:Avoid release to the environment. Refer to special instructions / safety data sheets.
WGK Germany 3
RTECS TL9100000

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
human	TDLo	oral	36mg/kg/25D-C (36mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)	American Journal of Psychiatry. Vol. 119, Pg. 465, 1962.
mouse	LD50	intraperitoneal	120mg/kg (120mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 148, Pg. 560, 1964.
mouse	LD50	intravenous	45mg/kg (45mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 148, Pg. 560, 1964.
mouse	LD50	oral	443mg/kg (443mg/kg)		Rassegna di Studi Psichiatrici. Review of Psychiatric Studies. Vol. 52, Pg. 204, 1963.
mouse	LD50	subcutaneous	315mg/kg (315mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 148, Pg. 560, 1964.
rabbit	LD50	intravenous	11mg/kg (11mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 148, Pg. 560, 1964.
rat	LD50	intraperitoneal	95mg/kg (95mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 148, Pg. 560, 1964.
rat	LD50	intravenous	32mg/kg (32mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 148, Pg. 560, 1964.
rat	LD50	oral	900mg/kg (900mg/kg)		Drugs in Japan Vol. 6, Pg. 161, 1982.
rat	LD50	subcutaneous	497mg/kg (497mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 148, Pg. 560, 1964.