| man |
TDLo |
oral |
3918ug/kg (3.918mg/kg) |
GASTROINTESTINAL: OTHER CHANGES |
Kiso to Rinsho. Clinical Report. Vol. 27, Pg. 6087, 1993. |
| man |
TDLo |
oral |
89mg/kg/25D-I (89mg/kg) |
LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
American Journal of Gastroenterology. Vol. 93, Pg. 459, 1998. |
| mouse |
LD50 |
intravenous |
393mg/kg (393mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: ATAXIA
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
"Proceedings of the International Congress of Chemotherapy, 13th, Vienna, 1983," Spitzy, K.H. and K. Karrer, eds., 18 vols., Vienna, Austria, Verlag H. Egermann, 1983Vol. 6, Pg. 116/52, 1983. |
| mouse |
LD50 |
oral |
4gm/kg (4000mg/kg) |
? |
Drugs of the Future. Vol. 9, Pg. 427, 1984. |
| rat |
LD50 |
intravenous |
213mg/kg (213mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: ATAXIA
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
"Proceedings of the International Congress of Chemotherapy, 13th, Vienna, 1983," Spitzy, K.H. and K. Karrer, eds., 18 vols., Vienna, Austria, Verlag H. Egermann, 1983Vol. 6, Pg. 116/52, 1983. |
| rat |
LD50 |
oral |
4gm/kg (4000mg/kg) |
? |
Drugs of the Future. Vol. 9, Pg. 427, 1984. |
| women |
TDLo |
oral |
200mg/kg/40D- (200mg/kg) |
BEHAVIORAL: ANOREXIA (HUMAN
LIVER: "JAUNDICE, CHOLESTATIC"
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" |
Journal of Hepathology. Vol. 24, Pg. 753, 1996. |
| women |
TDLo |
oral |
210mg/kg/6W-I (210mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: CHANGE IN FUNCTION: TASTE |
Lancet. Vol. 340, Pg. 728, 1992. |
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