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noscapine hydrochloride hydrate cas no:912-60-7

Synonyms: -

Identification
Namenoscapine hydrochloride hydrate
CAS912-60-7
Synonyms-
EINECS(EC#)213-014-9
Molecular FormulaC22H23NO7?HCl
Molecular Weight449.88
Chemical Properties
storage temp2-8°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Safety Data

Hazard Xi:Irritant;
Risk R22
Safety

Poison by intravenous route. Moderately toxic by ingestion and subcutaneous routes. Mutation data reported. When heated to decomposition it emits very toxic fumes of HCl and NOx.
Hazard Codes HarmfulXn,Xi
Risk Statements 22
R22:Harmful if swallowed.
Safety Statements 36
S36:Wear suitable protective clothing.
RIDADR 1544
WGK Germany 3
RTECS NP7225000
F 10
HazardClass 6.1(b)
PackingGroup III


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 52mg/kg (52mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED
Journal of Pharmacology and Experimental Therapeutics. Vol. 123, Pg. 287, 1958.
guinea pig LDLo intravenous 83mg/kg (83mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 119, Pg. 205, 1959.
mouse LD50 intraperitoneal 581mg/kg (581mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. Vol. 57, Pg. 538, 1961.
mouse LD50 oral 853mg/kg (853mg/kg)   Yakugaku Zasshi. Journal of Pharmacy. Vol. 81, Pg. 266, 1961.
mouse LD50 subcutaneous 700mg/kg (700mg/kg)   United States Patent Document. Vol. #3031377

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