92-13-7|2(3H)-Furanone,3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, (3S,4R)-Products Supply

2(3H)-Furanone,3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, (3S,4R)- cas no:92-13-7

Synonyms: 2(3H)-Furanone,3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, (3S-cis)-; Pilocarpine(8CI); (+)-Pilocarpine; Ocucarpine; Ocusert P 20; Ocusert Pilo; Ocusert Pilo40; Pilocarpine, (+)-; Pilocarpol; Pilokarpin; Syncarpine

Identification

Name2(3H)-Furanone,3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, (3S,4R)-
CAS92-13-7
Synonyms2(3H)-Furanone,3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, (3S-cis)-; Pilocarpine(8CI); (+)-Pilocarpine; Ocucarpine; Ocusert P 20; Ocusert Pilo; Ocusert Pilo40; Pilocarpine, (+)-; Pilocarpol; Pilokarpin; Syncarpine
EINECS(EC#)202-128-4
Molecular FormulaC11H16 N2 O2
Molecular Weight208.29

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(b)

Safety Data

Hazard T+: Very toxic;
Risk 26/28
Safety

A human poison by subcutaneous route. Poison experimentally by ingestion, intravenous, intraperitoneal, and subcutaneous routes. A very poisonous alkaloid that is used to remove excess fluid accumulations from the body. Its action on the sweat glands makes it a powerful sudorific. It very rarely causes death, but, when it does, it is by paralysis of the heart or edema of the lungs. Dangerous; on heating to decomposition it emits toxic fumes of NO_x.
Hazard Codes: Very T+
Risk Statements: 26/28
R26/28:Very toxic by inhalation and if swallowed.
Safety Statements: 25-45
S25:Avoid contact with eyes.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
human	LDLo	subcutaneous	143ug/kg (0.143mg/kg)	BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: CYANOSIS VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION	Confinia Neurologica. Vol. 10, Pg. 8, 1949.
man	LDLo	unreported	1912ug/kg (1.912mg/kg)		"Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970.
mouse	LD50	intraperitoneal	220mg/kg (220mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 192, Pg. 88, 1971.
mouse	LD50	intravenous	61900ug/kg (61.9mg/kg)		Drugs in Japan Vol. 6, Pg. APP-16, 1982.
mouse	LD50	oral	119mg/kg (119mg/kg)		Drugs in Japan Vol. 6, Pg. APP-16, 1982.
mouse	LD50	subcutaneous	90900ug/kg (90.9mg/kg)		Drugs in Japan Vol. 6, Pg. APP-16, 1982.
rabbit	LDLo	intravenous	120mg/kg (120mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1386, 1935.
rat	LD50	intraperitoneal	166mg/kg (166mg/kg)		Drugs in Japan Vol. 6, Pg. APP-16, 1982.
rat	LD50	intravenous	88500ug/kg (88.5mg/kg)		Drugs in Japan Vol. 6, Pg. APP-16, 1982.
rat	LD50	oral	402mg/kg (402mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 1204, 1981.
rat	LD50	subcutaneous	366mg/kg (366mg/kg)		Drugs in Japan Vol. 6, Pg. APP-16, 1982.
women	TDLo	subcutaneous	1143ug/kg (1.143mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS SKIN AND APPENDAGES (SKIN): SWEATING: OTHER	Archives of Ophthalmology Vol. 105, Pg. 25, 1987.

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2(3H)-Furanone,3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-, (3S,4R)- cas no:92-13-7

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