92077-78-6|6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylicacid, 9-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-,hydrate (1:1), (1S,9S)-Products Supply

6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylicacid, 9-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-,hydrate (1:1), (1S,9S)- cas no:92077-78-6

Synonyms: 6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylicacid, 9-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-,monohydrate, (1S,9S)- (9CI);6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylicacid, 9-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-,monohydrate, [1S-[1a,9a(R*)]]-;Cilazapril monohydrate;(1S,9S)-9-(((S)-1-Carboxy-3-phenylpropyl)amino)octahydro-10-;Cilazapril;Cilazapril monohydrate;UNII-19KW7PI29F;Inhibace;

Identification

Name6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylicacid, 9-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-,hydrate (1:1), (1S,9S)-
CAS92077-78-6
Synonyms6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylicacid, 9-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-,monohydrate, (1S,9S)- (9CI);6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylicacid, 9-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-,monohydrate, [1S-[1a,9a(R*)]]-;Cilazapril monohydrate;(1S,9S)-9-(((S)-1-Carboxy-3-phenylpropyl)amino)octahydro-10-;Cilazapril;Cilazapril monohydrate;UNII-19KW7PI29F;Inhibace;
Molecular FormulaC₂₂H₃₁N₃O₅.H₂O
Molecular Weight435.58

Safety Data

Safety

A poison by intravenous route. Moderately toxic by subcutaneous and intraperitoneal routes. Human systemic effects by ingestion: dermatitis. When heated to decomposition it emits toxic vapors of NO_x.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
monkey	LD50	oral	> 4gm/kg (4000mg/kg)		Cardiovascular Drug Reviews. Vol. 8, Pg. 1, 1990.
mouse	LD50	intraperitoneal	1300mg/kg (1300mg/kg)		Cardiovascular Drug Reviews. Vol. 8, Pg. 1, 1990.
mouse	LD50	intravenous	> 30mg/kg (30mg/kg)		Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 17, Pg. 1281, 1989.
mouse	LD50	subcutaneous	> 1gm/kg (1000mg/kg)	skin and appendages (skin): "dermatitis, other: after systemic exposure" skin and appendages (skin): hair: other	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 17, Pg. 1281, 1989.
mouse	LDLo	oral	5gm/kg (5000mg/kg)	behavioral: altered sleep time (including change in righting reflex) behavioral: convulsions or effect on seizure threshold	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 17, Pg. 1281, 1989.
rat	LD50	intraperitoneal	830mg/kg (830mg/kg)		Cardiovascular Drug Reviews. Vol. 8, Pg. 1, 1990.
rat	LD50	intravenous	> 30mg/kg (30mg/kg)		Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 17, Pg. 1281, 1989.
rat	LD50	oral	> 5gm/kg (5000mg/kg)	gastrointestinal: changes in structure or function of salivary glands gastrointestinal: "hypermotility, diarrhea"	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 17, Pg. 1281, 1989.
rat	LD50	subcutaneous	> 1gm/kg (1000mg/kg)	skin and appendages (skin): "dermatitis, other: after systemic exposure" behavioral: regidity	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 17, Pg. 1281, 1989.
women	TDLo	oral	15mg/kg/22W-I (15mg/kg)	skin and appendages (skin): "dermatitis, other: after systemic exposure"	Lancet. Vol. 345, Pg. 398, 1995.

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6H-Pyridazino[1,2-a][1,2]diazepine-1-carboxylicacid, 9-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-,hydrate (1:1), (1S,9S)- cas no:92077-78-6

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