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Glimepiride cas no:93479-97-1

Synonyms: 1h-pyrrole-1-carboxamide,2,5-dihydro-3-ethyl-4-methyl-n-(2-(4-(((((4-methylcyc; glimepirid; hoe490; trans-lohexyl)amino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-oxo; 1-[[p-[2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl]phenyl]sulfonyl]-3-(trans-4-methylcyclohexyl)urea; amary; AMARYL; Glimpiride

Identification
NameGlimepiride
CAS93479-97-1
Synonyms1h-pyrrole-1-carboxamide,2,5-dihydro-3-ethyl-4-methyl-n-(2-(4-(((((4-methylcyc; glimepirid; hoe490; trans-lohexyl)amino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-oxo; 1-[[p-[2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl]phenyl]sulfonyl]-3-(trans-4-methylcyclohexyl)urea; amary; AMARYL; Glimpiride
Molecular FormulaC24H34N4O5S
Molecular Weight490.62
Chemical Properties
AppearanceWhite Cyrstalline Solid
refractive index1.599
storage tempRoom temp
Safety Data

Hazard Xn,Xi
Risk R21
Safety

Hazard Codes:?HarmfulXn,IrritantXi
Risk Statements: 21-36/38-46-62-63?
R21:Harmful in contact with skin.?
R36/38:Irritating to eyes and skin.?
R46:May cause heritable genetic damage.?
R62:Risk of impaired fertility.?
R63:Possible risk of harm to the unborn child.
Safety Statements: 25-26-36/37-53
S25:Avoid contact with eyes.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36/37:Wear suitable protective clothing and gloves.?
S53:Avoid exposure - obtain special instructions before use.
WGK Germany: 3
RTECS: UX9363950


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo oral 28ug/kg/2D-I (0.028mg/kg) BLOOD: HEMORRHAGE
BLOOD: THROMBOCYTOPENIA
SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Annals of Pharmacotherpy. Vol. 34, Pg. 120, 2000.
mouse LD50 unreported > 10gm/kg (10000mg/kg) ? Diabetes Frontier. Vol. 3, Pg. 565, 1992.
rat LD intraperitoneal > 3950mg/kg (3950mg/kg) LIVER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 43, Pg. 547, 1993.
rat LD oral > 10gm/kg (10000mg/kg) LIVER: OTHER CHANGES Arzneimittel-Forschung. Drug Research. Vol. 43, Pg. 547, 1993.
rat LD50 unreported > 10gm/kg (10000mg/kg) ? Diabetes Frontier. Vol. 3, Pg. 565, 1992.

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ZHEJIANG CHEMIALS IM & EXP CORP.
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CNCCC SICHUAN IMPORT/EXPORT CO.,LTD.
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Nexchem Pharmaceutical Co.,Ltd.
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ZunAn Commerce & Industrial Co., Ltd.
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CHONGQING TRUST LONG CO.,LTD.
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Lianyungang Guiyuan Chempharm Co.,Ltd.
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CIDIC Co.,Ltd.
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Chongqing Yawei Fine Chemical Co., Ltd.
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King Sun Chemical & Pharmaceutical Co., Ltd.
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N-Techem International Co.Ltd.
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Auro Laboratories Limited
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BSM Chemical Import & Export Co., Ltd.
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Suzhou Tianma Pharma Group Specialty Chemical Co.,
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Address: 199 East Hua Yuan Rd, Mudu, Suzhou 215101,
Gudia Private Limited
Tel:+92-(21)-453-9101
Address: 6th Floor, Mehdi Towers SMCHS, Shahrah-e-Faisal, Karachi, Sindh 74400,

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