FLUVASTATIN SODIUM cas no:93957-55-2

NameFLUVASTATIN SODIUM
CAS93957-55-2
Synonymsfluvastatin sodium salt; sodium (3r,5s,6e)-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1h-indol-2-yl]-3,5-dihydroxy-6-heptenoate
Molecular FormulaC24H25FNNaO4
Molecular Weight433.45

AppearanceLight yellow solid powder
storage tempDesiccate at -20°C

Safety

Contraindications:
1)Hypersensitivity to drug
2)Active hepatic disease
3)Severe renal impairment
4)Pregnancy or breastfeeding
?

CHEMICAL IDENTIFICATION

RTECS NUMBER :

MJ9675100

CHEMICAL NAME :

6-Heptenoic acid, 3,5-dihydro-7-(3-(4-fluorophenyl)-1-(1-methylethyl)-1 H-indol-2-yl)-, monosodium salt, (R*,S*-(E))-, (+-)-

CAS REGISTRY NUMBER :

93957-55-2

LAST UPDATED :

199612

DATA ITEMS CITED :

3

MOLECULAR FORMULA :

C24-H26-F-N-O4.Na

MOLECULAR WEIGHT :

434.50

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

2912 mg/kg/26W-I

TOXIC EFFECTS :

Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - lipids including transport

REFERENCE :

FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 29,48,1996

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Mammal - dog

DOSE/DURATION :

5824 mg/kg/2Y-I

TOXIC EFFECTS :

Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :

FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 29,48,1996 ** REPRODUCTIVE DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Oral

DOSE :

396 mg/kg

SEX/DURATION :

female 7-17 day(s) after conception

TOXIC EFFECTS :

Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :

KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 29,853,1995