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Tetracaine cas no:94-24-6

Synonyms: Benzoicacid, p-(butylamino)-, 2-(dimethylamino)ethyl ester (8CI);2-Dimethylaminoethylp-butylaminobenzoate;Amethocaine;Ametop;Anetain;Butylocaine;Contralgin;Fissucain;Intercain;Laudocaine;Medicaine;Medihaler-Tetracaine;Meethobalm;Metraspray;Mucaesthin;Pontocaine;Rexocaine;Uromucaesthin;b-Dimethylaminoethylp-N-butylaminobenzoate;b-Dimethylaminoethyl p-butylaminobenzoate;

Identification
NameTetracaine
CAS94-24-6
SynonymsBenzoicacid, p-(butylamino)-, 2-(dimethylamino)ethyl ester (8CI);2-Dimethylaminoethylp-butylaminobenzoate;Amethocaine;Ametop;Anetain;Butylocaine;Contralgin;Fissucain;Intercain;Laudocaine;Medicaine;Medihaler-Tetracaine;Meethobalm;Metraspray;Mucaesthin;Pontocaine;Rexocaine;Uromucaesthin;b-Dimethylaminoethylp-N-butylaminobenzoate;b-Dimethylaminoethyl p-butylaminobenzoate;
EINECS(EC#)202-316-6
Molecular FormulaC15H24N2O2
Molecular Weight264.37
Chemical Properties
AppearanceWhite crystalline powder
refractive index1.537
storage temp2-8°C
Safety Data

Hazard Xn:Harmful
Risk R22;R40;R42/43
Safety

A human poison by parenteral route with systemic effects including: muscle contractions, coma, and cyanosis. A poison experimentally by intravenous, parenteral, intratracheal, intraperitoneal, and subcutaneous routes. Human mutation data reported. A local anesthetic. See also ESTERS. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes:Xn,Xi
Xi:Irritant
Xn:Harmful
Risk Statements
R22:Harmful if swallowed.
R40:Limited evidence of a carcinogenic effect.
R42/43:May cause sensitization by inhalation and skin contact .
R43:May cause sensitization by skin contact.
Safety Statements
S22:Do not breathe dust .
S36/37:Wear suitable protective clothing and gloves .
RIDADR:UN 2811
RTECS:DG4725000  


Toxicity
1.    

dnd-esc 30 µmol/L

    MUREAV    Mutation Research. 89 (1981),95.
2.    

dns-hmn:hla 1 µmol/L

    BCPCA6    Biochemical Pharmacology. 14 (1965),205.
3.    

par-man LDLo:1 mg/kg:CNS,PUL

    SAVEAB    Sammlung von Vergiftungsfaellen. 10 (1939),50.
4.    

ivn-rat LD50:6 mg/kg

    ARZNAD    Arzneimittel-Forschung. Drug Research. 8 (1958),539.
5.    

ipr-mus LD50:20 mg/kg

    RPTOAN    Russian Pharmacology and Toxicology. Translation of FATOAO. 35 (3)(1972),114.
6.    

scu-mus LD50:25 mg/kg

    PHTXA6    Pharmacology and Toxicology. Translation of FATOAO. 20 (1957),521.
7.    

ivn-mus LD50:6 mg/kg

    EJMCA5    European Journal of Medicinal Chemistry. Chimie Therapeutique. 10 (1975),291.
8.    

scu-rbt LDLo:20 mg/kg

    AEPPAE    Naunyn-Schmiedeberg’s Archiv fuer Experimentelle Pathologie und Pharmakologie. 160 (1931),53.
9.    

ivn-rbt LDLo:6 mg/kg

    AEPPAE    Naunyn-Schmiedeberg’s Archiv fuer Experimentelle Pathologie und Pharmakologie. 160 (1931),53.
10.    

par-rbt LD50:33,500 µg/kg

    ARZNAD    Arzneimittel-

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