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Benzenepropanoic acid, a-ethyl-3-hydroxy-2,4,6-triiodo- cas no:96-84-4

Synonyms: Hydrocinnamicacid, a-ethyl-3-hydroxy-2,4,6-triiodo-(6CI,7CI,8CI); (?à)-Iophenoxicacid; 2-(3-Hydroxy-2,4,6-triiodobenzyl)butyric acid; Iodoprol; Iophenoic acid;Iophenoxic acid; Jodoprol; Teridax; Trilombrine; a-(2,4,6-Triiodo-3-hydroxybenzyl)butyric acid; a-Ethyl-3-hydroxy-2,4,6-triiodohydrocinnamicacid; a-Ethyl-b-(3-hydroxy-2,4,6-triiodophenyl)propionicacid

Identification
NameBenzenepropanoic acid, a-ethyl-3-hydroxy-2,4,6-triiodo-
CAS96-84-4
SynonymsHydrocinnamicacid, a-ethyl-3-hydroxy-2,4,6-triiodo-(6CI,7CI,8CI); (?à)-Iophenoxicacid; 2-(3-Hydroxy-2,4,6-triiodobenzyl)butyric acid; Iodoprol; Iophenoic acid;Iophenoxic acid; Jodoprol; Teridax; Trilombrine; a-(2,4,6-Triiodo-3-hydroxybenzyl)butyric acid; a-Ethyl-3-hydroxy-2,4,6-triiodohydrocinnamicacid; a-Ethyl-b-(3-hydroxy-2,4,6-triiodophenyl)propionicacid
Molecular FormulaC11H11 I3 O3
Molecular Weight571.92
Chemical Properties
refractive index1.724
Safety Data

Hazard Xn: Harmful;
Risk 22-36/37/38
Safety

Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. When heated to decomposition it emits toxic fumes of I.

Hazard Codes HarmfulXn
Risk Statements 22-36/37/38
R22: Iophenoxic acid (CAS NO.96-84-4) is harmful if swallowed. 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements 26-37/39
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S37/39: When Iophenoxic acid (CAS NO.96-84-4) is used ,wear suitable gloves and eye/face protection.
WGK Germany 3
RTECS MW5280000


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 203mg/kg (203mg/kg) CARDIAC: PULSE RATE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 476, 1953.
guinea pig LD50 intraperitoneal 570mg/kg (570mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ANTIPSYCHOTIC

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 476, 1953.
mouse LD50 intraperitoneal 440mg/kg (440mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ANTIPSYCHOTIC

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 476, 1953.
mouse LD50 intravenous 374mg/kg (374mg/kg)   Journal of Medicinal Chemistry. Vol. 13, Pg. 997, 1970.
mouse LD50 oral 1850mg/kg (1850mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ANTIPSYCHOTIC

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 476, 1953.
rat LD50 intraperitoneal 648mg/kg (648mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ANTIPSYCHOTIC

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 476, 1953.
rat LD50 oral 2gm/kg (2000mg/kg)   Pharmazie. Vol. 12, Pg. 315, 1957.

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