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Troglitazone cas no:97322-87-7

Synonyms: (+/-)-5-[4-[(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedione

Identification
NameTroglitazone
CAS97322-87-7
Synonyms(+/-)-5-[4-[(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedione
Molecular FormulaC24H27NO5S
Molecular Weight441.54
Chemical Properties
AppearanceYellow solid.
storage tempThis product should be stored at room temperature. It should be kept in a tightly closed container.
Safety Data

Safety

Safety Information of Troglitazone (CAS NO.97322-87-7):
Safety Statements: 22-24/25
22:  Do not breathe dust 
24:  Avoid contact with skin 
25:  Avoid contact with eyes 


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
monkey LD50 oral > 2gm/kg (2000mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 38, Pg. 1121, 1996.
mouse LD oral > 300mg/kg (300mg/kg)   European Patent Application. Vol. #439321,
mouse LD50 intraperitoneal > 5gm/kg (5000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995.
mouse LD50 intravenous 42mg/kg (42mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 9, Pg. 759, 1967.
rat LD50 intraperitoneal > 4gm/kg (4000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995.
rat LD50 oral > 5gm/kg (5000mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 953, 1995.
women TDLo oral 840mg/kg/15W- (840mg/kg) BRAIN AND COVERINGS: ENCEPHALITIS

LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), DIFFUSE"

LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED"
Annals of Internal Medicine. Vol. 129, Pg. 98, 1998.

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Ramidus AB
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LKT Laboratories, Inc.
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