2-Furaldehyde cas no:98-01-1

Name2-Furaldehyde
CAS98-01-1
Synonyms2-Formyl furan; 2-furanaldehyde; 2-furancarbonal; 2-furancarboxaldehyde; 2-furfural; 2-furylmethanal; alpha-Furfuraldehyde; alpha-furole; artificial ant oil; artificial oil of ants; Fufural; Fural; Furaldehyde; Furfural; Furfuraldehyde; Pyromucic aldehyde; U1199
EINECS(EC#)202-627-7
Molecular FormulaC5H4O2
Molecular Weight96.08

Appearancecolourless to reddish-brown oily liquid with almond odour
refractive index1.525-1.527
storage temp2-8°C
Sensitive Air Sensitive

Hazardclass6.1

Hazard T:Toxic
Risk R21;R23/25;R36/37;R40
Safety

Confirmed carcinogen. Poison by ingestion, intraperitoneal, subcutaneous, intravenous, and intramuscular routes. Moderately toxic by inhalation and skin contact. Human mutation data reported. A skin and eye irritant. Mutation data reported. The liquid is dangerous to the eyes. The vapor is irritating to mucous membranes and is a central nervous system poison. However, its low volatility reduces its toxicity effect. Ingestion of furfural has produced cirrhosis of the liver in rats. In industry there is a tendency to minimize the danger of acute effects resulting from exposure to it. This is particularly true because of its low volatility.
Flammable liquid when exposed to heat or flame; can react with oxidizing materials. Moderate explosion hazard when exposed to heat or flame or by chemical reaction. An exothermic polymerization of almost explosive violence can occur upon contact with strong mineral acids or alkalies. Keep away from heat and open flames. Mixture with sodium hydrogen carbonate ignites spontaneously. To fight fire, use alcohol foam, CO₂, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes.
Hazard Codes: XiT
Risk Statements: 21-23/25-36/37-40 
R21: Harmful in contact with skin
R23/25: Toxic by inhalation and if swallowed
R36/37: Irritating to eyes and respiratory system
R40: Limited evidence of a carcinogenic effect
Safety Statements: 26-36/37/39-45-1/2 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
S36/37/39: Wear suitable protective clothing, gloves and eye/face protection
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S1/2: Keep locked up and out of the reach of children
RIDADR: UN 1199 6.1/PG 2
WGK Germany: 2
RTECS: LT7000000
F: 1-8-10
F 1: Sensitive to air and humidity
F 8: Photosensitive
F 9: Keep under nitrogen
F 10: Keep under argon
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: II
Contact with furfural irritates the skin and respiratory tract and can cause the lungs to fill with fluid.When ingested or inhaled, furfural can cause intoxication, including euphoria, nausea, headache, dizziness, and eventual unconsciousness and death due to respiratory failure. 
Chronic skin exposure can lead to a skin allergy to the substance, as well as an unusual susceptibility to sunburn. 

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LC50	inhalation	370ppm/6H (370ppm)		"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 279, 1969.
dog	LD50	intravenous	250mg/kg (250mg/kg)		Food and Cosmetics Toxicology. Vol. 16, Pg. 759, 1978.
dog	LD50	oral	950mg/kg (950mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA GASTROINTESTINAL: NAUSEA OR VOMITING	"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 279, 1969.
dog	LD50	subcutaneous	214mg/kg (214mg/kg)		Food and Cosmetics Toxicology. Vol. 16, Pg. 759, 1978.
frog	LDLo	parenteral	23gm/kg (23000mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 21, Pg. 65, 1923.
guinea pig	LD50	oral	541mg/kg (541mg/kg)	LIVER: "HEPATITIS (HEPATOCELLULAR NECROSIS), ZONAL" KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" BLOOD: HEMORRHAGE	Hygiene and Sanitation Vol. 32(5), Pg. 158, 1967.
guinea pig	LDLo	subcutaneous	100mg/kg (100mg/kg)		Food and Cosmetics Toxicology. Vol. 16, Pg. 759, 1978.
human	TCLo	inhalation	310ug/m3 (0.31mg/m3)		Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 26(6), Pg. 3, 1961.
mouse	LCLo	inhalation	370ppm/6H (370ppm)		"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 279, 1969.
mouse	LD50	intraperitoneal	102mg/kg (102mg/kg)		Food and Cosmetics Toxicology. Vol. 16, Pg. 759, 1978.
mouse	LD50	intravenous	152mg/kg (152mg/kg)		Food and Cosmetics Toxicology. Vol. 16, Pg. 759, 1978.
mouse	LD50	oral	400mg/kg (400mg/kg)		Biochemical Journal. Vol. 34, Pg. 1196, 1940.
mouse	LD50	subcutaneous	119mg/kg (119mg/kg)		Food and Cosmetics Toxicology. Vol. 16, Pg. 759, 1978.
rabbit	LD50	intramuscular	78mg/kg (78mg/kg)		Food and Cosmetics Toxicology. Vol. 16, Pg. 759, 1978.
rabbit	LDLo	oral	800mg/kg (800mg/kg)	PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Journal of Pharmacology and Experimental Therapeutics. Vol. 21, Pg. 65, 1923.
rabbit	LDLo	skin	620mg/kg (620mg/kg)		Food and Cosmetics Toxicology. Vol. 16, Pg. 759, 1978.
rabbit	LDLo	subcutaneous	500mg/kg (500mg/kg)		Hygiene and Sanitation Vol. 32(5), Pg. 158, 1967.
rat	LC50	inhalation	175ppm/6H (175ppm)	LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	American Industrial Hygiene Association Journal. Vol. 50, Pg. A359, 1989.
rat	LD50	intraperitoneal	20mg/kg (20mg/kg)		Food and Cosmetics Toxicology. Vol. 16, Pg. 759, 1978.
rat	LD50	oral	65mg/kg (65mg/kg)		Bromatologia i Chemia Toksykologiczna. Vol. 13, Pg. 371, 1980.
rat	LD50	subcutaneous	148mg/kg (148mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 279, 1969.