Piperidine,1-[2-[3-(2,2-diphenylethyl)-1,2,4-oxadiazol-5-yl]ethyl]-, hydrochloride (1:1) cas no:982-43-4

NamePiperidine,1-[2-[3-(2,2-diphenylethyl)-1,2,4-oxadiazol-5-yl]ethyl]-, hydrochloride (1:1)
CAS982-43-4
SynonymsPiperidine,1-[2-[3-(2,2-diphenylethyl)-1,2,4-oxadiazol-5-yl]ethyl]-, monohydrochloride(8CI,9CI); HK 256; Libeksin; Libexin; Lomapect; Prenoxdiazine; Tibexin
EINECS(EC#)213-567-6
Molecular FormulaC23H27 N3 O . Cl H
Molecular Weight397.99

Safety

Poison by intravenous route. Moderately toxic by ingestion and subcutaneous routes. Used as an antitussive agent. When Libexin (CAS NO.982-43-4) is heated to decomposition, it emits very toxic fumes of NO_x and HCl.

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intravenous	34mg/kg (34mg/kg)	AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"	Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 617, 1966.
mouse	LD50	oral	920mg/kg (920mg/kg)	AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"	Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 617, 1966.
mouse	LD50	subcutaneous	540mg/kg (540mg/kg)		Bollettino Chimico Farmaceutico. Vol. 112, Pg. 691, 1973.
rat	LD50	intravenous	32mg/kg (32mg/kg)	AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"	Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 617, 1966.
rat	LDLo	oral	> 2gm/kg (2000mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 16, Pg. 617, 1966.