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1,1,1,3,3,3-Hexamethyldisilazane cas no:999-97-3

Synonyms: HMDS; Hexamethyldisilazane; DYNASYLAN HMDS; Bis(trimethylsilyl)amine; 1,1,1,3,3,3,-HEXAMETHYLDISILA-

Identification
Name1,1,1,3,3,3-Hexamethyldisilazane
CAS999-97-3
SynonymsHMDS; Hexamethyldisilazane; DYNASYLAN HMDS; Bis(trimethylsilyl)amine; 1,1,1,3,3,3,-HEXAMETHYLDISILA-
EINECS(EC#)213-668-5
Molecular FormulaC6H19NSi2
Molecular Weight161.39
Chemical Properties
AppearanceClear liquid
refractive index1.4069-1.4089
storage temp2-8°C
Sensitive Moisture Sensitive
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass3
Safety Data

Hazard C:Corrosive
Risk R11;R20/21/22;R34
Safety

Moderately toxic by ingestion and intraperitoneal routes. Questionable carcinogen with experimental tumorigenic data. A dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidizing materials. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes: ?F,? C,? Xn
The Risk Statements information of? Hexamethyldisilazane (CAS NO.999-97-3):
11:? Highly Flammable?
34:? Causes burns?
20/21/22:? Harmful by inhalation, in contact with skin and if swallowed?
The Safety Statements information of? Hexamethyldisilazane (CAS NO.999-97-3):
16:? Keep away from sources of ignition - No smoking?
26:? In case of contact with eyes, rinse immediately with plenty of water and seek medical advice?
45:? In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)?
36/37/39:? Wear suitable protective clothing, gloves and eye/face protection?
RIDADR: UN 3286 3/PG 2
WGK Germany: 2
RTECS: JM9230000
F: 21
Hazard Note: Flammable
TSCA: Yes
HazardClass: 3
PackingGroup: II


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 skin 1mL/kg (1mL/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: MUSCLE WEAKNESS

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
National Technical Information Service. Vol. OTS0537734,
mouse LC50 inhalation 12gm/m3/2H (12000mg/m3) BEHAVIORAL: GENERAL ANESTHETIC

CARDIAC: PULSE RATE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 30(5), Pg. 52, 1986.
mouse LD50 intravenous > 100mg/kg (100mg/kg) ? Interagency Collaborative Group on Environmental Carcinogenesis, National Cancer Institute, Memorandum, June 17, 1974Vol. 17JUN1974,
mouse LD50 oral 850mg/kg (850mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

CARDIAC: PULSE RATE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 30(5), Pg. 52, 1986.
mouse LDLo intraperitoneal 650mg/kg (650mg/kg) IMMUNOLOGICAL INCLUDING ALLERGIC: DECREASED IMMUNE RESPONSE Personal Communication from G.D. Stoner, Dept. of Community Medicine, School of Medicine, Univ. of California, La Jolla, CA 92037, May 25, 1975Vol. 27MAY1975,
rabbit LD50 oral 1100mg/kg (1100mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

CARDIAC: PULSE RATE
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 30(5), Pg. 52, 1986.
rabbit LD50 skin 710uL/kg (0.71mL/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 12, Pg. 576, 1993.
rat LC50 inhalation 8700mg/m3/4H (8700mg/m3) BEHAVIORAL: GENERAL ANESTHETIC

CARDIAC: PULSE RATE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 30(5), Pg. 52, 1986.
rat LD50 intraperitoneal 800mg/kg (800mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: MUSCLE WEAKNESS

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
National Technical Information Service. Vol. OTS0537734,
rat LD50 oral 850mg/kg (850mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

CARDIAC: PULSE RATE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 30(5), Pg. 52, 1986.

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