Phosphonic acid,P,P'-(dichloromethylene)bis- cas no:10596-23-3

NamePhosphonic acid,P,P'-(dichloromethylene)bis-
CAS10596-23-3
SynonymsPhosphonicacid, (dichloromethylene)bis- (9CI); Phosphonic acid, (dichloromethylene)di-(8CI); (Dichloromethylene)bis[phosphonic acid]; Cl 2MDP; Clodronate; Clodronicacid; DMDP; Dichloromethylenediphosphonic acid; Methanedichlorodiphosphonicacid
EINECS(EC#)234-212-1
Molecular FormulaCH4 Cl2 O6 P2
Molecular Weight244.89

refractive index1.598

CHEMICAL IDENTIFICATION

RTECS NUMBER :

SZ7640500

CHEMICAL NAME :

Phosphonic acid, (dichloromethylene)bis-

CAS REGISTRY NUMBER :

10596-23-3

LAST UPDATED :

199612

DATA ITEMS CITED :

3

MOLECULAR FORMULA :

C-H4-Cl2-O6-P2

MOLECULAR WEIGHT :

244.89

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Oral

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

2500 mg/kg

TOXIC EFFECTS :

Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 266,1691,1993

TYPE OF TEST :

LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :

Subcutaneous

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

1600 mg/kg

TOXIC EFFECTS :

Details of toxic effects not reported other than lethal dose value

REFERENCE :

JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 266,1691,1993 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :

TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :

Intraperitoneal

SPECIES OBSERVED :

Rodent - rat

DOSE/DURATION :

800 mg/kg/4D-I

TOXIC EFFECTS :

Kidney, Ureter, Bladder - proteinuria Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - changes in iron

REFERENCE :

TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978- Volume(issue)/page/year: 15,365,1987