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Faropenem sodium cas no:122547-49-3

Synonyms: 4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylicacid, 6-(1-hydroxyethyl)-7-oxo-3-(tetrahydro-2-furanyl)-, monosodium salt,[5R-[3(R*),5a,6a(R*)]]-;4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid,6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-tetrahydro-2-furanyl]-, monosodium salt,(5R,6S)- (9CI);(5R,6S)-6-[(1R)-1-Hydroxyethyl]-7-oxo-3-[(2R)-2-tetrahydrofuryl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylicacid sodium salt;ALP 201;Farom;Fropenem;Furopenem;SY 5555;Wy 49605;Sun 5555;

Identification
NameFaropenem sodium
CAS122547-49-3
Synonyms4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylicacid, 6-(1-hydroxyethyl)-7-oxo-3-(tetrahydro-2-furanyl)-, monosodium salt,[5R-[3(R*),5a,6a(R*)]]-;4-Thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid,6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-tetrahydro-2-furanyl]-, monosodium salt,(5R,6S)- (9CI);(5R,6S)-6-[(1R)-1-Hydroxyethyl]-7-oxo-3-[(2R)-2-tetrahydrofuryl]-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylicacid sodium salt;ALP 201;Farom;Fropenem;Furopenem;SY 5555;Wy 49605;Sun 5555;
Molecular FormulaC12H14NNaO5S
Molecular Weight307.3
Chemical Properties
Appearancepale yellow crystals
Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 3gm/kg (3000mg/kg) ? Chemotherapy Vol. 42(Suppl,
dog LD50 intravenous > 1200mg/kg (1200mg/kg) ? Drugs of the Future. Vol. 18, Pg. 525, 1993.
mouse LD50 intravenous 3300mg/kg (3300mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

KIDNEY, URETER, AND BLADDER: INCONTINENCE
Chemotherapy Vol. 42(Suppl,
mouse LD50 oral > 2gm/kg (2000mg/kg) ? Drugs of the Future. Vol. 18, Pg. 525, 1993.
rat LD50 oral > 2gm/kg (2000mg/kg) ? Drugs of the Future. Vol. 18, Pg. 525, 1993.
rat LDLo intravenous 800mg/kg (800mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 25, Pg. 1781, 1997.

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