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Home > products > Piperazine,1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-,hydrochloride (1:2)

Piperazine,1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-,hydrochloride (1:2) cas no:129-74-8

Synonyms: Piperazine,1-(p-tert-butylbenzyl)-4-(p-chloro-a-phenylbenzyl)-, dihydrochloride (6CI,7CI,8CI);Piperazine,1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-,dihydrochloride (9CI);1-(p-tert-Butylbenzyl)-4-(p-chlorodiphenylmethyl)piperazine dihydrochloride;1-p-Chlorobenzhydryl-4-p-(t)-butylbenzylpiperazine dihydrochloride;Bucladin S;Buclina;Buclizine dihydrochloride;Buclodin;Histabutyzine hydrochloride;Longifene;NSC 25141;Vibazine;Vibazine Hydrochloride;

Identification
NamePiperazine,1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-,hydrochloride (1:2)
CAS129-74-8
SynonymsPiperazine,1-(p-tert-butylbenzyl)-4-(p-chloro-a-phenylbenzyl)-, dihydrochloride (6CI,7CI,8CI);Piperazine,1-[(4-chlorophenyl)phenylmethyl]-4-[[4-(1,1-dimethylethyl)phenyl]methyl]-,dihydrochloride (9CI);1-(p-tert-Butylbenzyl)-4-(p-chlorodiphenylmethyl)piperazine dihydrochloride;1-p-Chlorobenzhydryl-4-p-(t)-butylbenzylpiperazine dihydrochloride;Bucladin S;Buclina;Buclizine dihydrochloride;Buclodin;Histabutyzine hydrochloride;Longifene;NSC 25141;Vibazine;Vibazine Hydrochloride;
EINECS(EC#)204-962-4
Molecular FormulaC28H35Cl3N2
Molecular Weight433.03
Chemical Properties
AppearanceOff-White Powder
Safety Data

Safety

Poison by intraperitoneal route. An experimental teratogen. When heated to decomposition it emits very toxic fumes of NOx and HCl.


Toxicity
Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 430mg/kg (430mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: EXCITEMENT
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 43, Pg. 653, 1954.
mouse LD50 oral 2100mg/kg (2100mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: EXCITEMENT
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 43, Pg. 653, 1954.

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Fleming Laboratories Limited
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