13009-99-9|Mafenide acetateProducts Supply - Chemical intermediates Network

Mafenide acetate cas no:13009-99-9

Synonyms: Winthrocine;Mafenide acetate (JAN/USP);p-Toluenesulfonamide, alpha-amino-, monoacetate;Sulfamylon (TN);alpha-Aminotoluene-4-sulphonamide monoacetate;α-aminotoluene-4-sulphonamide monoacetate;Mafenide acetate (USP31);Mafenide acetate [USAN:JAN];alpha-Amino-p-toluenesulfonamide monoacetate;Maphenide acetate;Benzenesulfonamide, 4-(aminomethyl)-, monoacetate;p-Aminomethylbenzenesulfonamide acetate;4-(Aminomethyl)benzenesulfonamide monoacetate;acetic acid; 4-(aminomethyl)benzenesulfonamide;Sulfamilon;

Identification

NameMafenide acetate
CAS13009-99-9
SynonymsWinthrocine;Mafenide acetate (JAN/USP);p-Toluenesulfonamide, alpha-amino-, monoacetate;Sulfamylon (TN);alpha-Aminotoluene-4-sulphonamide monoacetate;α-aminotoluene-4-sulphonamide monoacetate;Mafenide acetate (USP31);Mafenide acetate [USAN:JAN];alpha-Amino-p-toluenesulfonamide monoacetate;Maphenide acetate;Benzenesulfonamide, 4-(aminomethyl)-, monoacetate;p-Aminomethylbenzenesulfonamide acetate;4-(Aminomethyl)benzenesulfonamide monoacetate;acetic acid; 4-(aminomethyl)benzenesulfonamide;Sulfamilon;
EINECS(EC#)235-855-0
Molecular FormulaC₇H₁₀N₂O₂S^.C₂H₄O₂
Molecular Weight246.28346

Chemical Properties

AppearanceCrystalline Solid

Safety Data

Safety

Moderately toxic by intravenous and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. Used as an antibacterial agent. When heated to decomposition it emits very toxic fumes of NO_x and SO_x.
Safety information of Mafenide acetate (CAS NO.13009-99-9):
WGK Germany: 3

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	oral	5425mg/kg (5425mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(8), Pg. 50, 1987.
mammal (species unspecified)	LC	inhalation	> 320mg/m³ (320mg/m³)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(8), Pg. 50, 1987.
mouse	LD50	intraperitoneal	2322mg/kg (2322mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(8), Pg. 50, 1987.
mouse	LD50	intravenous	1580mg/kg (1580mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Life Sciences. Vol. 5, Pg. 2279, 1966.
mouse	LD50	oral	10183mg/kg (10183mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(8), Pg. 50, 1987.
mouse	LD50	subcutaneous	> 5gm/kg (5000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS	Yakkyoku. Pharmacy. Vol. 30, Pg. 1517, 1979.
rat	LD50	intraperitoneal	1560mg/kg (1560mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 884, 1979.
rat	LD50	intravenous	1730mg/kg (1730mg/kg)		Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 884, 1979.
rat	LD50	oral	9212mg/kg (9212mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(8), Pg. 50, 1987.
rat	LD50	subcutaneous	> 5gm/kg (5000mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS	Yakkyoku. Pharmacy. Vol. 30, Pg. 1517, 1979.

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Mafenide acetate cas no:13009-99-9

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