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Cupferron cas no:135-20-6

Synonyms: N-Hydroxy-N-nitrosobenzenamine ammonium salt; N-Nitroso-N-phenylhydroxyamine ammonium salt; Cupferron for analysis; copperone

Identification
NameCupferron
CAS135-20-6
SynonymsN-Hydroxy-N-nitrosobenzenamine ammonium salt; N-Nitroso-N-phenylhydroxyamine ammonium salt; Cupferron for analysis; copperone
EINECS(EC#)205-183-2
Molecular FormulaC6H9N3O2
Molecular Weight155.15
Chemical Properties
Appearancewhite or golden leprose crystal
storage temp2-8°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1
Safety Data

Hazard T:Toxic;
Risk R25;R36/37/38;R40
Safety

Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by intravenous route. An eye irritant. Solutions with thorium salts are unstable explosives above 15°C. Solutions with titanium or zirconium salts are unstable explosives above 40°C. When heated to decomposition it emits very toxic NH3 and NOx. See also N-NITROSO COMPOUNDS and AMINES.
 

Hazard Codes: T
Risk Statements:
23:  Toxic by inhalation
24:  Toxic in contact with skin
25:  Toxic if swallowed
36:  Irritating to the eyes
37:  Irritating to the respiratory system
38:  Irritating to the skin
40:  Limited evidence of a carcinogenic effect
41:  Risk of serious damage to eyes
43:  May cause sensitization by skin contact
45:  May cause cancer
Safety Statements:
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:  Wear suitable protective clothing 
37:  Wear suitable gloves
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
53:  Avoid exposure - obtain special instruction before use


Toxicity
1.    

mmo-sat 100 µg/plate

    ENMUDM    Environmental Mutagenesis. 7 (Suppl 5)(1985),1.
2.    

cyt-grh-orl 1 ppm

    JCGEDO    Journal of Cytology and Genetics. 1 (1966),75.
3.    

eye-rbt 20 mg/24 H MOD

    85JCAE    Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,510.
4.    

orl-rat TDLo:123 g/kg/78 W-C:CAR

    NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-100 ,1978.
5.    

orl-mus TDLo:437 g/kg/78 W-C:CAR

    NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-100 ,1978.
6.    

orl-rat TD:9040 mg/kg/65 W-C:ETA

    ZEKBAI    Zeitschrift fuer Krebsforschung. 69 (1967),103.
7.    

orl-rat LD50:199 mg/kg

    GTPZAB    Gigiena Truda i Professionalnye Zabolevaniia. Labor Hygiene and Occupational Diseases. 32 (3)(1988),48.
8.    

ipr-rat LDLo:50 mg/kg

    KODAK*    Kodak Company Reports. (343 State St., Rochester, NY 14650)
9.    

ivn-mus LD50:180 mg/kg

    CSLNX*    U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) NX#04968 .

Carcinogenicity: Cupferron - California: carcinogen, initial date 1/1/88 NTP: Suspect carcinogen

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