man |
TDLo |
parenteral |
16gm/kg/34W-I (16000mg/kg) |
CARDIAC: PERICARDITIS
GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE
BLOOD: OTHER CHANGES |
American Journal of Kidney Diseases. Vol. 10, Pg. 71, 1987. |
man |
TDLo |
subcutaneous |
143mg/kg/4D-I (143mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
GASTROINTESTINAL: NAUSEA OR VOMITING |
British Medical Journal. Vol. 291, Pg. 448, 1985. |
mouse |
LD50 |
intraperitoneal |
1240mg/kg (1240mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 1181, 1973. |
mouse |
LD50 |
intravenous |
273mg/kg (273mg/kg) |
|
Drugs in Japan Vol. 6, Pg. 496, 1982. |
mouse |
LD50 |
oral |
15200mg/kg (15200mg/kg) |
|
Drugs in Japan Vol. 6, Pg. 496, 1982. |
mouse |
LD50 |
subcutaneous |
1280mg/kg (1280mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 1181, 1973. |
rat |
LD50 |
intravenous |
330mg/kg (330mg/kg) |
|
Drugs in Japan Vol. 6, Pg. 496, 1982. |
rat |
LD50 |
oral |
17300mg/kg (17300mg/kg) |
|
Drugs in Japan Vol. 6, Pg. 496, 1982. |
rat |
LD50 |
subcutaneous |
5500mg/kg (5500mg/kg) |
|
Drugs in Japan Vol. 6, Pg. 496, 1982. |
women |
TDLo |
subcutaneous |
150mg/kg/4D-I (150mg/kg) |
GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
GASTROINTESTINAL: NAUSEA OR VOMITING |
British Medical Journal. Vol. 291, Pg. 448, 1985. |
women |
TDLo |
unreported |
900mg/kg/30W- (900mg/kg) |
BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES
CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION
LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA |
American Journal of Medicine. Vol. 87, Pg. 468, 1989. |