138-14-7|Deferoxamine mesylateProducts Supply - Chemical intermediates Network

Deferoxamine mesylate cas no:138-14-7

Synonyms: Deferoxamine mesilate (JP14);Desferal;Prestwick_988;Deferoxamine mesylate (USP);Butanediamide,N'-[5-[[4-[[5-(acetylhydroxyamino) pentyl]amino]-1,4-dioxobutyl]hydroxyamino] pentyl]-N-(5-aminopentyl)-Nhydroxy-,monomethanesulfonate (salt);Desferal (TN);

Identification

NameDeferoxamine mesylate
CAS138-14-7
SynonymsDeferoxamine mesilate (JP14);Desferal;Prestwick_988;Deferoxamine mesylate (USP);Butanediamide,N'-[5-[[4-[[5-(acetylhydroxyamino) pentyl]amino]-1,4-dioxobutyl]hydroxyamino] pentyl]-N-(5-aminopentyl)-Nhydroxy-,monomethanesulfonate (salt);Desferal (TN);
EINECS(EC#)205-314-3
Molecular FormulaC₂₅H₄₈N₆O₈^.CH₄O₃S
Molecular Weight656.78968

Chemical Properties

Appearancewhite to off-white powder
storage temp−20°C

Safety Data

Safety

Safety Information of Deferoxamine mesylate (CAS NO.138-14-7):
Safety Statements: 22-24/25
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
WGK Germany: 2
RTECS: UG5310000
Poison by intravenous route. Moderately toxic by subcutaneous and intraperitoneal routes. Mildly toxic by ingestion. Human systemic effects: acute pulmonary edema, blood changes, cardiomyopathy, degenerative brain changes, diarrhea, hypermotility, nausea or vomiting, pericarditis, ulceration or bleeding from small intestine, visual field changes. When heated to decomposition it emits toxic fumes of NO_x and SO_x.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	parenteral	16gm/kg/34W-I (16000mg/kg)	CARDIAC: PERICARDITIS GASTROINTESTINAL: ULCERATION OR BLEEDING FROM SMALL INTESTINE BLOOD: OTHER CHANGES	American Journal of Kidney Diseases. Vol. 10, Pg. 71, 1987.
man	TDLo	subcutaneous	143mg/kg/4D-I (143mg/kg)	SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING	British Medical Journal. Vol. 291, Pg. 448, 1985.
mouse	LD50	intraperitoneal	1240mg/kg (1240mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 1181, 1973.
mouse	LD50	intravenous	273mg/kg (273mg/kg)		Drugs in Japan Vol. 6, Pg. 496, 1982.
mouse	LD50	oral	15200mg/kg (15200mg/kg)		Drugs in Japan Vol. 6, Pg. 496, 1982.
mouse	LD50	subcutaneous	1280mg/kg (1280mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 1181, 1973.
rat	LD50	intravenous	330mg/kg (330mg/kg)		Drugs in Japan Vol. 6, Pg. 496, 1982.
rat	LD50	oral	17300mg/kg (17300mg/kg)		Drugs in Japan Vol. 6, Pg. 496, 1982.
rat	LD50	subcutaneous	5500mg/kg (5500mg/kg)		Drugs in Japan Vol. 6, Pg. 496, 1982.
women	TDLo	subcutaneous	150mg/kg/4D-I (150mg/kg)	GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" GASTROINTESTINAL: NAUSEA OR VOMITING	British Medical Journal. Vol. 291, Pg. 448, 1985.
women	TDLo	unreported	900mg/kg/30W- (900mg/kg)	BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES CARDIAC: CARDIOMYOPATHY INCLUDING INFARCTION LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA	American Journal of Medicine. Vol. 87, Pg. 468, 1989.

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Deferoxamine mesylate cas no:138-14-7

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