141396-28-3|Argatroban monohydrateProducts Supply - Chemical intermediates Network

Argatroban monohydrate cas no:141396-28-3

Synonyms: 2-Piperidinecarboxylicacid,1-[(2S)-5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-,monohydrate, (2R,4R)- (9CI);2-Piperidinecarboxylic acid,1-[5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-,monohydrate, [2R-[1(2S*),2a,4b]]-[partial]-;2-Piperidinecarboxylicacid,1-[(2S)-5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-,hydrate (1:1), (2R,4R)-;

Identification

NameArgatroban monohydrate
CAS141396-28-3
Synonyms2-Piperidinecarboxylicacid,1-[(2S)-5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-,monohydrate, (2R,4R)- (9CI);2-Piperidinecarboxylic acid,1-[5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-,monohydrate, [2R-[1(2S*),2a,4b]]-[partial]-;2-Piperidinecarboxylicacid,1-[(2S)-5-[(aminoiminomethyl)amino]-1-oxo-2-[[(1,2,3,4-tetrahydro-3-methyl-8-quinolinyl)sulfonyl]amino]pentyl]-4-methyl-,hydrate (1:1), (2R,4R)-;
Molecular FormulaC₂₃H₃₆N₆O₅S^.H₂O
Molecular Weight526.65

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	475mg/kg (475mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA BLOOD: NORMOCYTIC ANEMIA	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14(Suppl,
mouse	LD50	intravenous	> 81mg/kg (81mg/kg)	BLOOD: HEMORRHAGE	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14(Suppl,
mouse	LD50	oral	> 15gm/kg (15000mg/kg)	BLOOD: HEMORRHAGE BLOOD: NORMOCYTIC ANEMIA	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14(Suppl,
mouse	LD50	subcutaneous	3750mg/kg (3750mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BLOOD: NORMOCYTIC ANEMIA SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14(Suppl,
rat	LD50	intraperitoneal	320mg/kg (320mg/kg)	SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BLOOD: NORMOCYTIC ANEMIA	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14(Suppl,
rat	LD50	intravenous	> 81mg/kg (81mg/kg)	BLOOD: HEMORRHAGE	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14(Suppl,
rat	LD50	oral	> 15gm/kg (15000mg/kg)	BLOOD: HEMORRHAGE BLOOD: NORMOCYTIC ANEMIA	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14(Suppl,
rat	LD50	subcutaneous	620mg/kg (620mg/kg)	LUNGS, THORAX, OR RESPIRATION: DYSPNEA BLOOD: NORMOCYTIC ANEMIA SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"	Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 14(Suppl,

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Argatroban monohydrate cas no:141396-28-3

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