L-threo-a-D-galacto-Octopyranoside, methyl7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio- cas no:18323-44-9
Synonyms: L-threo-D-galacto-Octopyranoside,methyl7-chloro-6,7,8-trideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-,trans- a- (8CI);L-threo-a-D-galacto-Octopyranoside, methyl7-chloro-6,7,8-trideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-,(2S-trans)-;7(S)-Chloro-7-deoxylincomycin;7-Chloro-7-deoxylincomycin;7-Chlorolincomycin;7-Deoxy-7(S)-chlorolincomycin;Antirobe;Chlolincocin;Cleocin;ClindaDerm;Clindamycin;Clinimycin;Dalacin C;Dalacin V;Dalacine;Klimicin;Klindan 300;Sobelin;U 21251;
NameL-threo-a-D-galacto-Octopyranoside, methyl7-chloro-6,7,8-trideoxy-6-[[[(2S,4R)-1-methyl-4-propyl-2-pyrrolidinyl]carbonyl]amino]-1-thio-
CAS18323-44-9
SynonymsL-threo-D-galacto-Octopyranoside,methyl7-chloro-6,7,8-trideoxy-6-(1-methyl-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-,trans- a- (8CI);L-threo-a-D-galacto-Octopyranoside, methyl7-chloro-6,7,8-trideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-,(2S-trans)-;7(S)-Chloro-7-deoxylincomycin;7-Chloro-7-deoxylincomycin;7-Chlorolincomycin;7-Deoxy-7(S)-chlorolincomycin;Antirobe;Chlolincocin;Cleocin;ClindaDerm;Clindamycin;Clinimycin;Dalacin C;Dalacin V;Dalacine;Klimicin;Klindan 300;Sobelin;U 21251;
EINECS(EC#)242-209-1
Molecular FormulaC18H33ClN2O5S
Molecular Weight424.98
Appearancewhite crystalline powder
Hazard UN NO.
Safety
Hydrochloride salt of Clindamycin (CAS NO.18323-44-9): adults with severe infections, 1 150 ~ 300mg, if necessary, can be increased to 450mg, every 6 hours 1: Children with severe infection of 1 per kilogram of body weight 8 ~ 16mg, if necessary, per kilogram of body weight may be increased to 20mg, is divided into 3 to 4 times to give. 2. Palmitate hydrochloride (for children to use): severe infection, 1 per kilogram body weight 8 ~ 12mg, very serious, per kilogram body weight may be increased to 20 ~ 25mg, were divided into 3 to 4 times to give. Below 10kg weight infants may be 1 per kg body weight 8 ~ 12mg medication, were divided into three sub-grant. 3. Phosphate (injection): Adults gram-positive aerobic infections, 1, 600 ~ 1200mg, divided into 2 to 4 times intramuscular injection or infusion; anaerobic infections, tends to be used on the 1st 1200 ~ 2700mg, very serious Infection can be used to daily 4800mg. Children 1 month old or more severe infections on the 1st volume per kg body weight 15 ~ 25mg, very serious per kilogram body weight may be 25 ~ 40mg, were divided into 3 to 4 times application. Intramuscular injection of a meeting does not exceed the amount of 600mg, more than this amount should be given intravenously. Intravenous drug use should be preceded by the liquid dilution, 600mg of drug should be added no less than 100ml of infusion, the infusion of at least 20 minutes. Within 1 hour infusion dose should not exceed 1200mg.
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| hamster |
LDLo |
oral |
1mg/kg (1mg/kg) |
Gastrointestinal: other changes |
Arzneimittel-Forschung. Drug Research. Vol. 34, Pg. 794, 1984.
|
| rabbit |
LDLo |
oral |
1mg/kg (1mg/kg) |
|
Recueil de Medecine Veterinaire. Vol. 156, Pg. 915, 1980. |
| rat |
LD50 |
subcutaneous |
2618mg/kg (2618mg/kg) |
|
Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971.
|
