2058-52-8|clothiapineProducts Supply - Chemical intermediates Network

clothiapine cas no:2058-52-8

Synonyms: 2-Chloro-11-(4-methylpiperazino)dibenzo(b,f)(1,4)thiazepine

Identification

Nameclothiapine
CAS2058-52-8
Synonyms2-Chloro-11-(4-methylpiperazino)dibenzo(b,f)(1,4)thiazepine
EINECS(EC#)218-162-8
Molecular FormulaC18H18 Cl N3 S
Molecular Weight343.90

Chemical Properties

refractive index1.69

Safety Data

Safety

Poison by ingestion. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition Clothiapine (CAS NO.2058-52-8) emits very toxic fumes of Cl⁻, NO_x, and SO_x.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Source
guinea pig	LD50	oral	150mg/kg (150mg/kg)	Toxicology and Applied Pharmacology. Vol. 14, Pg. 657, 1969.
mouse	LD50	intramuscular	160mg/kg (160mg/kg)	Drugs in Japan Vol. 6, Pg. 234, 1982.
mouse	LD50	intravenous	46mg/kg (46mg/kg)	Drugs in Japan Vol. 6, Pg. 234, 1982.
mouse	LD50	oral	270mg/kg (270mg/kg)	Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 841, 1965.
mouse	LD50	subcutaneous	348mg/kg (348mg/kg)	Drugs in Japan Vol. 6, Pg. 234, 1982.
rat	LD50	intramuscular	> 300mg/kg (300mg/kg)	Drugs in Japan Vol. 6, Pg. 233, 1982.
rat	LD50	intravenous	47mg/kg (47mg/kg)	Drugs in Japan Vol. -, Pg. 404, 1995.
rat	LD50	oral	280mg/kg (280mg/kg)	Drugs in Japan Vol. 6, Pg. 234, 1982.
rat	LD50	subcutaneous	> 500mg/kg (500mg/kg)	Drugs in Japan Vol. 6, Pg. 233, 1982.

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clothiapine cas no:2058-52-8

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