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clenbuterol hydrochloride cas no:21898-19-1

Synonyms: Clenbuterol Hhydrochloride; Clenbuterol HCl

Identification
Nameclenbuterol hydrochloride
CAS21898-19-1
SynonymsClenbuterol Hhydrochloride; Clenbuterol HCl
EINECS(EC#)244-643-7
Molecular FormulaC12H18Cl2N2O?HCl
Molecular Weight313.65106
Chemical Properties
AppearanceColourless microcrystalline powder
storage temp2-8°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Safety Data

Hazard T:Toxic
Risk R25
Safety

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and HCl.
Safety Information of Ventipulmin (21898-19-1):
Hazard Codes: T
Risk Statements: 25 
25:  Toxic if swallowed
Safety Statements: 22-36/37/39-45
22:  Do not breathe dust
36:  Wear suitable protective clothing  
37:  Wear suitable gloves 
39:  Wear eye/face protection 
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo intravenous 45mg/kg (45mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1420, 1976.
dog LDLo oral 500mg/kg (500mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1420, 1976.
guinea pig LD50 intravenous 12600ug/kg (12.6mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1420, 1976.
guinea pig LD50 subcutaneous 67100ug/kg (67.1mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1420, 1976.
mouse LD50 intraperitoneal 46mg/kg (46mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

CARDIAC: CHANGE IN RATE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 675, 1975.
mouse LD50 intravenous 27600ug/kg (27.6mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1420, 1976.
mouse LD50 oral 147mg/kg (147mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 15, Pg. 741, 1984.
mouse LD50 subcutaneous 63mg/kg (63mg/kg) SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 15, Pg. 741, 1984.
rabbit LD50 intravenous 12600ug/kg (12.6mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1404, 1976.
rabbit LD50 subcutaneous 67100ug/kg (67.1mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1404, 1976.
rat LD50 intraperitoneal 67mg/kg (67mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

CARDIAC: CHANGE IN RATE

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 675, 1975.
rat LD50 intravenous 35300ug/kg (35.3mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1420, 1976.
rat LD50 oral 159mg/kg (159mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 15, Pg. 741, 1984.
rat LD50 subcutaneous 148mg/kg (148mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 15, Pg. 741, 1984.

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