dog |
LDLo |
intravenous |
45mg/kg (45mg/kg) |
|
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1420, 1976. |
dog |
LDLo |
oral |
500mg/kg (500mg/kg) |
|
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1420, 1976. |
guinea pig |
LD50 |
intravenous |
12600ug/kg (12.6mg/kg) |
|
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1420, 1976. |
guinea pig |
LD50 |
subcutaneous |
67100ug/kg (67.1mg/kg) |
|
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1420, 1976. |
mouse |
LD50 |
intraperitoneal |
46mg/kg (46mg/kg) |
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
CARDIAC: CHANGE IN RATE
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION |
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 675, 1975. |
mouse |
LD50 |
intravenous |
27600ug/kg (27.6mg/kg) |
|
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1420, 1976. |
mouse |
LD50 |
oral |
147mg/kg (147mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
SKIN AND APPENDAGES (SKIN): HAIR: OTHER |
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 15, Pg. 741, 1984. |
mouse |
LD50 |
subcutaneous |
63mg/kg (63mg/kg) |
SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS |
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 15, Pg. 741, 1984. |
rabbit |
LD50 |
intravenous |
12600ug/kg (12.6mg/kg) |
|
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1404, 1976. |
rabbit |
LD50 |
subcutaneous |
67100ug/kg (67.1mg/kg) |
|
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1404, 1976. |
rat |
LD50 |
intraperitoneal |
67mg/kg (67mg/kg) |
BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
CARDIAC: CHANGE IN RATE
LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION |
Oyo Yakuri. Pharmacometrics. Vol. 9, Pg. 675, 1975. |
rat |
LD50 |
intravenous |
35300ug/kg (35.3mg/kg) |
|
Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1420, 1976. |
rat |
LD50 |
oral |
159mg/kg (159mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: ATAXIA |
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 15, Pg. 741, 1984. |
rat |
LD50 |
subcutaneous |
148mg/kg (148mg/kg) |
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
LUNGS, THORAX, OR RESPIRATION: DYSPNEA |
Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 15, Pg. 741, 1984. |