24356-60-3|5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 3-[(acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-, sodiumsalt (1:1)Products Supply

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 3-[(acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-, sodiumsalt (1:1) cas no:24356-60-3

Synonyms: 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 3-(hydroxymethyl)-8-oxo-7-[2-(4-pyridylthio)acetamido]-, acetate (ester),monosodium salt (8CI); 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[(acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-, monosodiumsalt, (6R,7R)- (9CI); 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[(acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-, monosodiumsalt, (6R-trans)-; 7-[a-(4-Pyridylthio)acetamido]cephalosporanic acid sodium salt; Ambrocef; BLP1322; Brisfirina; Bristocef; Cef-Lak; Cefa-Lak; Cefadyl; Cefaloject; Cefapirinsodium; Cefaprin sodium; Cefatrexyl; Cephapirin sodium; Cephatrexil; NSC179171; Piricef; Sodium cefapirin; Sodium cephapirin; Today

Identification

Name5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 3-[(acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-, sodiumsalt (1:1)
CAS24356-60-3
Synonyms5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 3-(hydroxymethyl)-8-oxo-7-[2-(4-pyridylthio)acetamido]-, acetate (ester),monosodium salt (8CI); 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[(acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-, monosodiumsalt, (6R,7R)- (9CI); 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,3-[(acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-, monosodiumsalt, (6R-trans)-; 7-[a-(4-Pyridylthio)acetamido]cephalosporanic acid sodium salt; Ambrocef; BLP1322; Brisfirina; Bristocef; Cef-Lak; Cefa-Lak; Cefadyl; Cefaloject; Cefapirinsodium; Cefaprin sodium; Cefatrexyl; Cephapirin sodium; Cephatrexil; NSC179171; Piricef; Sodium cefapirin; Sodium cephapirin; Today
EINECS(EC#)246-194-2
Molecular FormulaC17H17 N3 O6 S2 . Na
Molecular Weight446.48

Chemical Properties

storage temp0-6°C

Safety Data

Hazard Xn:Harmful
Risk R36/37/38;R42/43
Safety

Moderately toxic by intravenous route. Human systemic effects by intramuscular route: fever, white blood cell effects (angranulocytosis), interstitial nephritis. Mildly toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NO_x, Na₂O, and SO_x. See also ESTERS.
Hazard Codes of Cephapirin sodium (CAS NO.24356-60-3):? Harmful Xn
Risk Statements: 36/37/38-42/43?
R36/37/38:Irritating to eyes, respiratory system and skin.?
R42/43:May cause sensitization by inhalation and skin contact.
Safety Statements: 26-36?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S36:Wear suitable protective clothing.

Toxicity

1.	???	ims-dog TDLo:24?g/kg (30D pre):REP	???	OYYAA2 ?? Oyo Yakuri. Pharmacometrics. 9 (1975),11.
2.	???	ivn-man TDLo:7429?μg/kg/8W-I:KID	???	DICPBB ?? Drug Intelligence and Clinical Pharmacy. 21 (1987),380.
3.	???	ims-man TDLo:350?mg/kg/6D:BLD,MET	???	AMACCQ ?? Antimicrobial Agents and Chemotherapy. 1 (1972),174.
4.	???	orl-rat LD50:16,356?mg/kg	???	NIIRDN ?? “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),405.
5.	???	ipr-rat LD50:7850?mg/kg	???	NIIRDN ?? “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),405.
6.	???	ivn-rat LD50:4580?mg/kg	???	ARZNAD ?? Arzneimittel-Forschung. Drug Research. 29 (1979),424.
7.	???	orl-mus LD50:26,088?mg/kg	???	NIIRDN ?? “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),405.
8.	???	ipr-mus LD50:8899?mg/kg	???	NIIRDN ?? “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),405.
9.	???	scu-mus LD50:13,556?mg/kg	???	NIIRDN ?? “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical

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5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid, 3-[(acetyloxy)methyl]-8-oxo-7-[[(4-pyridinylthio)acetyl]amino]-, sodiumsalt (1:1) cas no:24356-60-3

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