8-Isoquinolinamine,1,2,3,4-tetrahydro-2-methyl-4-phenyl- cas no:24526-64-5
Synonyms: Isoquinoline,8-amino-1,2,3,4-tetrahydro-2-methyl-4-phenyl- (8CI); (?à)-Nomifensin; (?à)-Nomifensine; 2-Methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-ylamine;Linamiphen; Nomifensin; Nomifensine
Name8-Isoquinolinamine,1,2,3,4-tetrahydro-2-methyl-4-phenyl-
CAS24526-64-5
SynonymsIsoquinoline,8-amino-1,2,3,4-tetrahydro-2-methyl-4-phenyl- (8CI); (?à)-Nomifensin; (?à)-Nomifensine; 2-Methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-8-ylamine;Linamiphen; Nomifensin; Nomifensine
Molecular FormulaC16H18 N2
Molecular Weight238.33
refractive index1.622
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Hazard Xn: Harmful;
Risk 22-36/37/38
Safety
Poison by ingestion and intravenous routes. Human systemic effects by ingestion: diffuse hepatitis, hemorrhage and decrease in the number of blood platelets (thrombocytopenia). When heated to decomposition it emits toxic fumes of NOx. See also NOMIFENSINE MALEATE.
Hazard Codes 
Xn
Risk Statements 22-36/37/38
R22: Nomifensine (CAS NO.24526-64-5) is harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements 26-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
RIDADR 3249
WGK Germany 3
RTECS NX4912800
HazardClass 6.1(b)
PackingGroup III
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| guinea pig |
LD50 |
intravenous |
264mg/kg (264mg/kg) |
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES |
Drugs. International Journal of Current Therapeutics and Applied Pharmacology Reviews. Vol. 18, Pg. 1, 1979. |
| mammal (species unspecified) |
LD50 |
oral |
300mg/kg (300mg/kg) |
|
German Offenlegungsschrift Patent Document. Vol. #2901868, |
| mouse |
LD50 |
intraperitoneal |
128mg/kg (128mg/kg) |
|
Journal de Pharmacologie. Vol. 17, Pg. 37, 1986. |
| mouse |
LD50 |
oral |
260mg/kg (260mg/kg) |
BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)
BEHAVIORAL: AGGRESSION |
Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 873, 1982. |
| mouse |
LD50 |
subcutaneous |
269mg/kg (269mg/kg) |
|
United States Patent Document. Vol. #4537895, |
| rat |
LD50 |
oral |
267mg/kg (267mg/kg) |
|
Journal of International Medical Research. Vol. 13, Pg. 77, 1985. |
| women |
TDLo |
oral |
500ug/kg (0.5mg/kg) |
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD |
Human Toxicology. Vol. 6, Pg. 247, 1987. |
| women |
TDLo |
oral |
7mg/kg/7D-I (7mg/kg) |
BLOOD: HEMORRHAGE
BLOOD: THROMBOCYTOPENIA |
British Medical Journal. Vol. 288, Pg. 830, 1984. |
