26016-99-9|Disodium phosphonomycinProducts Supply - Chemical intermediates Network

Disodium phosphonomycin cas no:26016-99-9

Synonyms: Phosphonicacid, (1,2-epoxypropyl)-, disodium salt, (1R,2S)-(-)- (8CI);Disodium fosfomycin;FOM-Na;Fosfocin;Fosfomycindisodium salt;Fosmicin S;Levo-phosphonomycin disodium salt;NSC 136017;Sodium fosfomycin;Phosphonicacid, P-[(2R,3S)-3-methyl-2-oxiranyl]-, sodium salt (1:2);

Identification

NameDisodium phosphonomycin
CAS26016-99-9
SynonymsPhosphonicacid, (1,2-epoxypropyl)-, disodium salt, (1R,2S)-(-)- (8CI);Disodium fosfomycin;FOM-Na;Fosfocin;Fosfomycindisodium salt;Fosmicin S;Levo-phosphonomycin disodium salt;NSC 136017;Sodium fosfomycin;Phosphonicacid, P-[(2R,3S)-3-methyl-2-oxiranyl]-, sodium salt (1:2);
EINECS(EC#)247-409-2
Molecular FormulaC₃H₅Na₂O₄P
Molecular Weight182.02

Chemical Properties

AppearanceWhite Solid
storage temp2-8°C

Safety Data

Hazard F: Flammable;C: Corrosive;
Risk R11
Safety

Poison by intraperitoneal and subcutaneous routes. Moderately toxic by intravenous and intramuscular routes. Mildly toxic by ingestion. Experimental teratogenic and reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of PO_x and Na₂O.
Hazard Codes: F,C
Risk Statements: 11-34
11:? Highly Flammable?
34:? Causes burns?
Safety Statements: 16-26-36/37/39-45
16:? Keep away from sources of ignition - No smoking?
26:? In case of contact with eyes, rinse immediately with plenty of water and seek medical advice?
36/37/39:? Wear suitable protective clothing, gloves and eye/face protection?
45:? In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)?
WGK Germany: 2
RTECS: SZ7902000
F: 10-21
F10: Keep under argon.
F21: Sensitive to humidity.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intramuscular	2625mg/kg (2625mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Japanese Journal of Antibiotics. Vol. 32, Pg. 61, 1979.
mouse	LD50	intraperitoneal	2175mg/kg (2175mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 668, 1981.
mouse	LD50	intravenous	1225mg/kg (1225mg/kg)	SENSE ORGANS AND SPECIAL SENSES: INCREASED INTRAOCULAR PRESSURE: EYE BEHAVIORAL: IRRITABILITY BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	Japanese Journal of Antibiotics. Vol. 32, Pg. 61, 1979.
mouse	LD50	oral	7300mg/kg (7300mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Japanese Journal of Antibiotics. Vol. 32, Pg. 61, 1979.
mouse	LD50	subcutaneous	5100mg/kg (5100mg/kg)	?	Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 12, Pg. 668, 1981.
rat	LD50	intramuscular	2460mg/kg (2460mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Japanese Journal of Antibiotics. Vol. 32, Pg. 61, 1979.
rat	LD50	intraperitoneal	2gm/kg (2000mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Japanese Journal of Antibiotics. Vol. 32, Pg. 61, 1979.
rat	LD50	intravenous	1560mg/kg (1560mg/kg)	SENSE ORGANS AND SPECIAL SENSES: INCREASED INTRAOCULAR PRESSURE: EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Japanese Journal of Antibiotics. Vol. 32, Pg. 61, 1979.
rat	LD50	oral	4550mg/kg (4550mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: MUSCLE WEAKNESS	Japanese Journal of Antibiotics. Vol. 32, Pg. 61, 1979.
rat	LD50	subcutaneous	4320mg/kg (4320mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Japanese Journal of Antibiotics. Vol. 32, Pg. 61, 1979. ?

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Disodium phosphonomycin cas no:26016-99-9

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