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Aristolochic acid I cas no:313-67-7

Synonyms: -

Identification
NameAristolochic acid I
CAS313-67-7
Synonyms-
EINECS(EC#)206-238-3
Molecular FormulaC17H11NO7
Molecular Weight341.27174
Chemical Properties
AppearanceYellow powder
storage temp2-8°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Safety Data

Hazard T:Toxic
Risk R25
Safety

Hazard Codes: ToxicT
Risk Statements: 25 
R25: Toxic if swallowed.
Safety Statements: 7-35-45 
S7: Keep container tightly closed. 
S35: This material and its container must be disposed of in a safe way. 
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 1544 6.1/PG 3
WGK Germany: 3
RTECS: CF3325000
HazardClass: 6.1(b)
PackingGroup: III
Confirmed carcinogen. Poison by ingestion, intraperitoneal, and intravenous routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intravenous 40mg/kg (40mg/kg) VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION
Farmakologiya i Toksikologiya Vol. 28, Pg. 74, 1965.
man LDLo intravenous 3mg/kg/2D-I (3mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" Cancer Chemotherapy Reports. Vol. 42, Pg. 35, 1964.
mouse LD50 intraperitoneal 14320ug/kg (14.32mg/kg)   Guangxi Yixue. Kuanghsi Medicine. Vol. (6), Pg. 2, 1981.
mouse LD50 intravenous 38400ug/kg (38.4mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Archives of Toxicology. Vol. 59, Pg. 328, 1987.
mouse LD50 oral 55900ug/kg (55.9mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Archives of Toxicology. Vol. 59, Pg. 328, 1987.
rabbit LDLo intraperitoneal 1500ug/kg (1.5mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS
Farmakologiya i Toksikologiya Vol. 28, Pg. 74, 1965.
rat LD50 intravenous 74mg/kg (74mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ATAXIA
Archives of Toxicology. Vol. 59, Pg. 328, 1987.
rat LD50 oral 184mg/kg (184mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Archives of Toxicology. Vol. 59, Pg. 328, 1987.

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