313-67-7|Aristolochic acid IProducts Supply - Chemical intermediates Network

Aristolochic acid I cas no:313-67-7

Synonyms: -

Identification

NameAristolochic acid I
CAS313-67-7
Synonyms-
EINECS(EC#)206-238-3
Molecular FormulaC17H11NO7
Molecular Weight341.27174

Chemical Properties

AppearanceYellow powder
storage temp2-8°C

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(b)

Safety Data

Hazard T:Toxic
Risk R25
Safety

Hazard Codes: Toxic T
Risk Statements: 25
R25: Toxic if swallowed.
Safety Statements: 7-35-45
S7: Keep container tightly closed.
S35: This material and its container must be disposed of in a safe way.
S45: In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 1544 6.1/PG 3
WGK Germany: 3
RTECS: CF3325000
HazardClass: 6.1(b)
PackingGroup: III
Confirmed carcinogen. Poison by ingestion, intraperitoneal, and intravenous routes. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	intravenous	40mg/kg (40mg/kg)	VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	Farmakologiya i Toksikologiya Vol. 28, Pg. 74, 1965.
man	LDLo	intravenous	3mg/kg/2D-I (3mg/kg)	KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"	Cancer Chemotherapy Reports. Vol. 42, Pg. 35, 1964.
mouse	LD50	intraperitoneal	14320ug/kg (14.32mg/kg)		Guangxi Yixue. Kuanghsi Medicine. Vol. (6), Pg. 2, 1981.
mouse	LD50	intravenous	38400ug/kg (38.4mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Archives of Toxicology. Vol. 59, Pg. 328, 1987.
mouse	LD50	oral	55900ug/kg (55.9mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Archives of Toxicology. Vol. 59, Pg. 328, 1987.
rabbit	LDLo	intraperitoneal	1500ug/kg (1.5mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: MUSCLE WEAKNESS	Farmakologiya i Toksikologiya Vol. 28, Pg. 74, 1965.
rat	LD50	intravenous	74mg/kg (74mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA	Archives of Toxicology. Vol. 59, Pg. 328, 1987.
rat	LD50	oral	184mg/kg (184mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Archives of Toxicology. Vol. 59, Pg. 328, 1987.

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Aristolochic acid I cas no:313-67-7

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