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Carbinoxamine maleate cas no:3505-38-2

Synonyms: 2-[p-Chloro-α-[2-(dimethylamino)ethoxy]benzyl]pyridine bimaleate;Lergefin;N-[2-[(4-Chlorophenyl)(2-pyridinyl)methoxy]ethyl]-N,N-dimethylamine maleate salt;Clistin maleate;p-Carbinoxamine maleate;Pyridine, 2-[p-chloro-.alpha.-[2- (dimethylamino)ethoxy]benzyl]-, maleate (1:1);Clistin;Allergefon maleate;Prestwick_238;Clistine Maleate;Ethanamine, 2-[(4-chlorophenyl)-2-pyridinylmethoxy]-N,N-dimethyl-, (2Z)-2-butenedioate (1:1);Ciberon;Paracarbinoxamine maleate;but-2-enedioic acid; 2-[(4-chlorophenyl)-pyridin-2-yl-methoxy]-N,N-dimethyl-ethanamine;

Identification
NameCarbinoxamine maleate
CAS3505-38-2
Synonyms2-[p-Chloro-α-[2-(dimethylamino)ethoxy]benzyl]pyridine bimaleate;Lergefin;N-[2-[(4-Chlorophenyl)(2-pyridinyl)methoxy]ethyl]-N,N-dimethylamine maleate salt;Clistin maleate;p-Carbinoxamine maleate;Pyridine, 2-[p-chloro-.alpha.-[2- (dimethylamino)ethoxy]benzyl]-, maleate (1:1);Clistin;Allergefon maleate;Prestwick_238;Clistine Maleate;Ethanamine, 2-[(4-chlorophenyl)-2-pyridinylmethoxy]-N,N-dimethyl-, (2Z)-2-butenedioate (1:1);Ciberon;Paracarbinoxamine maleate;but-2-enedioic acid; 2-[(4-chlorophenyl)-pyridin-2-yl-methoxy]-N,N-dimethyl-ethanamine;
EINECS(EC#)222-498-0
Molecular FormulaC16H19ClN2O.C4H4O4
Molecular Weight406.86
Chemical Properties
AppearanceOff-white solid
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Safety Data

Hazard T: Toxic;
Risk R25
Safety

Poison by ingestion, subcutaneous, and intravenous routes. Human systemic effects by ingestion: distorted perceptions, excitement hallucinations. When heated to decomposition it emits very toxic fumes of Cl and NOx.
 

Hazard Codes: ToxicT
Risk Statements:
25:  Toxic if swallowed
36:  Irritating to the eyes
37:  Irritating to the respiratory system
38:  Irritating to the skin
Safety Statements:
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:  Wear suitable protective clothing 
37:  Wear suitable gloves
39:  Wear eye/face protection
45:  In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)


Toxicity
1.    

orl-cld TDLo:1880 µg/kg/4D-I:BAH

    JTCTDW    Journal of Toxicology, Clinical Toxicology. 25 (1987),161.
2.    

orl-mus LD50:162 mg/kg

    CLDND*    Compilation of LD50 Values of New Drugs. 15 (1968),367.
3.    

scu-mus LD50:350 mg/kg

    TOIZAG    Toho Igakkai Zasshi. Journal of Medical Society of Toho University. 15 (1968),367.
4.    

ivn-mus LD50:32 mg/kg CLDND*

5.    

ivn-dog LDLo:36 mg/kg CLDND*

6.    

orl-gpg LD50:411 mg/kg CLDND*

7.    

scu-gpg LD50:120 mg/kg

    APFRAD    Annales Pharmaceutiques Francaises. 20 (1962),463.

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