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Home > products > Butanamide,N-[3-acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]-

Butanamide,N-[3-acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]- cas no:37517-30-9

Synonyms: (+-)-3'-Acetyl-4'-(2-hydroxy-3-(isopropylamino)propoxy)butyranilide;(RS)-Acebutolol;Monitan;dl-Acebutolol;

Identification
NameButanamide,N-[3-acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]-
CAS37517-30-9
Synonyms(+-)-3'-Acetyl-4'-(2-hydroxy-3-(isopropylamino)propoxy)butyranilide;(RS)-Acebutolol;Monitan;dl-Acebutolol;
EINECS(EC#)253-539-0
Molecular FormulaC18H28N2O4
Molecular Weight336.48
Chemical Properties
AppearanceCrystals.
refractive index1.542
storage tempKeep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
Safety Data

Safety

Moderately toxic by intravenous route. Human systemic effects by ingestion: developmental abnormalities of the cardiovascular and respiratory systems; effects on newborn in biochemical and metabolic abnormalities and reduced growth statistics. A human teratogen. When heated to decomposition it emits toxic fumes of NOx. A beta-adrenergic blocker.


Toxicity
Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 4mg/kg (4mg/kg) CARDIAC: CHANGE IN RATE
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
KIDNEY, URETER, AND BLADDER: CHANGES IN BLOOD VESSELS OR IN CIRCULATION OF KIDNEY
Masui to Sosei. Anesthesia and Resuscitation. Vol. 16, Pg. 13, 1980.
man TDLo oral 137mg/kg/24D- (137mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING
KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION
Annals of Internal Medicine. Vol. 111, Pg. 533, 1989.
mouse LD50 intravenous 75200ug/kg (75.2mg/kg)   Nouvelle Presse Medicale. Vol. 7, Pg. 3258, 1978.
mouse LD50 subcutaneous 125mg/kg (125mg/kg)   Cesko-Slovenska Farmacie. Vol. 42, Pg. 82, 1993.
women TDLo oral 109mg/kg/22D- (109mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING
KIDNEY, URETER, AND BLADDER: OTHER CHANGES IN URINE COMPOSITION
Annals of Internal Medicine. Vol. 111, Pg. 533, 1989.
women TDLo oral 152mg/kg (152mg/kg) CARDIAC: CHANGE IN CONDUCTION VELOCITY
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
Journal of Toxicology, Clinical Toxicology. Vol. 20, Pg. 69, 1983.

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YiPeng Chemical
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HangZhou Peak Chemical Co.,Ltd
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China Langchem Inc.
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Luna Chemicals Co.,Ltd.
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Levachem Co. Ltd.
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Conier Chem & Pharma Co.,Ltd.
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Address: 24 South Section 1, Yihuan Road, Chengdu, Sichuan 610065,
AOKChem Co., Ltd.
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Address: Room 203, Block D, No.333 Cailun Road, Zhangjiang High-tech Park, Shanghai 201203,
LGM Pharmaceuticals Inc.
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Wuhan Dahua Weiye Pharmaceutical Co.,Ltd
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Wuhan Dahua Weiye Pharmaceutical Co.,Ltd
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D Maniar and Brothers
Tel:+91-22-26105345锛?6105355
Address: 10, Shaniya Enclave, 5th FloorVallabhai RoadNear Railway Crossing Vile Parle (West) Mumbai - 400 056 INDIA.
SINOCHEM NINGBO LTD.
Tel:86-574-87260209 87348868
Address: 21 Jiangxia St.,Ningbo 315000 .Zhejiang. China
Yuanfang Chemical Co.,Ltd.
Tel:0086-512-53413633
Address: FuHao Developing zone, TaiCang City, JiangSu, China
Laboratoire SUBSTIPHARM
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Wenzhou Huaji Chemical CO.,LTD.
Tel:+86-577-88325242
Address: Rm.1-303 Jinyi Block Xueyuan Rd. Wenzhou

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