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clonidine hydrochloride cas no:4205-91-8

Synonyms: Clonidine Hcl; 2-(2,6-Dichloroanilino)-2-imidazoline hydrochloride

Identification
Nameclonidine hydrochloride
CAS4205-91-8
SynonymsClonidine Hcl; 2-(2,6-Dichloroanilino)-2-imidazoline hydrochloride
EINECS(EC#)224-121-5
Molecular FormulaC9H9Cl2N3?HCl
Molecular Weight266.56
Chemical Properties
storage temp2-8°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Safety Data

Hazard T+:Verytoxic;
Risk R25;R26
Safety

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: coma, effects on sleep, fall in blood pressure, gastrointestinal system effects, increase in pulse rate, pulse rate decrease, reduced blood pressure, respiratory depression, respiratory system effects, somnolence. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and Cl?.
Hazard Codes:?VeryT+
Risk Statements: 25-26?
R25 :Toxic if swallowed.?
R26:Very toxic by inhalation.
Safety Statements: 22-26-28-36/37/39-45?
S22:Do not breathe dust.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S28:After contact with skin, wash immediately with plenty of soap-suds.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2811 6.1/PG 1
WGK Germany: 3
RTECS: NJ2490000
F: 10
HazardClass: 6.1(b)
PackingGroup: III


Toxicity
1. ???

orl-inf TDLo:390?μg/kg

??? PEDIAU ?? Pediatrics. 72 (1983),500.
2. ???

orl-wmn TDLo:180?μg/kg:BAH,CVS,PUL

??? AJEMEN ?? American Journal of Emergency Medicine. 7 (1989),343.
3. ???

orl-inf TDLo:390?μg/kg:NAH,CVS

??? PEDIAU ?? Pediatrics. 72 (1983),500.
4. ???

orl-wmn TDLo:126?μg/kg/4?W-I:GIT

??? BMJOAE ?? British Medical Journal. 292 (1986),174.
5. ???

orl-man TDLo:69?μg/kg:CNS,CVS

??? LANCAO ?? Lancet. 2 (1976),694.
6. ???

orl-chd TDLo:70?μg/kg:CNS,CVS,PUL

??? AJDCAI ?? American Journal of Diseases of Children. 137 (1983),171.
7. ???

orl-rat LD50:126?mg/kg

??? IYKEDH ?? Iyakuhin Kenkyu. Study of Medical Supplies. 18 (1987),366.
8. ???

ipr-rat LD50:100?mg/kg

??? IYKEDH ?? Iyakuhin Kenkyu. Study of Medical Supplies. 9 (1978),829.
9. ???

scu-rat LD50:77?mg/kg

??? IYKEDH ?? Iyakuhin Kenkyu. Study of Medical Supplies. 18 (1987),366.
10. ???

ivn-rat LD50:29?mg/kg

??? ARZNAD ?? Arzneimittel-Forschung. Drug Research. 16 (1966),1038.
11.

supplier list

Tianjin Harmony Technology Development Co., Ltd.
Tel:
Address: Room 601 of BokeBuilding, 100 Fukang Road, Tianjin, China
Gyma Laboratories Of America, Inc.
Tel:+1-516-933-0900
Address: 135 Cantiague Rock Rd.Westbury, NY 11590
FAITH EAGLE (LABORATORY) LTD.
Tel:(+86-755) 82851290
Address: 15A/F.,Block A,World Trade Plaza,8# FuHong Rd., FuTian,Shenzhen, China
Healthy Life Pharma (P) Limited
Tel:+91-22-32403692/32459914
Address: 401, Richa, B-29, New Andheri Link Road, Andheri (W)
KOA SHOJI CO., LTD.
Tel:+81-45-540-6985
Address: 17-5, Minowa-cho, 2-chome, Kohoku-ku, Yokohama-shi, Kanagawa, 223-0051, Japan
J.INC.
Tel:+91 79 30903703
Address: 303, 3rd Floor, Royale Manor, Law Garden,Ellisbridge, Ahmedabad - 380006,Gujarat, India
Yunyang Group Co. Ltd.
Tel:+86-(511)-6980259, 6980388
Address: Economic Development Zone 8 on the 8th Latitude, Danyang, Jiangsu 212300,
Unichem Laboratories Ltd.
Tel:+91-(22)-2678 0643 / 2678 2644
Address: Prabhat Estate, Off S.V.Road,Jogeshwari (West), Mumbai, Maharashtra 400 102,
Tocris Bioscience
Tel:+1-(800)-421-3701
Address: 16144 Westwoods Business Park, Ellisville, Missouri 63021,
Sunstar Chem. & Pharm. Corp
Tel:+886-(6)-6 636 2898
Address: 112-2, Chung Cheng Road, Hsin-Yin,
Tecoland Corporation
Tel:+1-(732)-603-9577
Address: 100 Menlo Park Drive, Suite 316, Edison, New Jersey 08837-2428,
Trust & We Co., Ltd.
Tel:86-21-61551611
Address: 601, No. 1, 2277 Nong, Zu Chongzhi Road, Zhangjiang Hightech. Park, Pudong, Shanghai, China.
Shanghai Xunxin Chemical Co., Ltd
Tel:+86-(21)-38218795
Address: 580 Lane, Kanghong Road, Pudong New District, Shanghai 201315,
Changzhou Sinly Pharmchem Co., Ltd.
Tel:+86-(519)-86608206/88121371
Address: Room 516, Luckystar, No.218,Guanghua Street, Changzhou, Jiangsu 213001,
Changzhou Kangzheng Pharmachem Technology Co., Ltd.
Tel:+86-(519)-85109938
Address: No. 457, Chuangxin (North) Area, Science & Technology Park, Xinbei District, Changzhou, Jiangsu 213022,

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