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clonidine hydrochloride cas no:4205-91-8

Synonyms: Clonidine Hcl; 2-(2,6-Dichloroanilino)-2-imidazoline hydrochloride

Identification
Nameclonidine hydrochloride
CAS4205-91-8
SynonymsClonidine Hcl; 2-(2,6-Dichloroanilino)-2-imidazoline hydrochloride
EINECS(EC#)224-121-5
Molecular FormulaC9H9Cl2N3?HCl
Molecular Weight266.56
Chemical Properties
storage temp2-8°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(b)
Safety Data

Hazard T+:Verytoxic;
Risk R25;R26
Safety

Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: coma, effects on sleep, fall in blood pressure, gastrointestinal system effects, increase in pulse rate, pulse rate decrease, reduced blood pressure, respiratory depression, respiratory system effects, somnolence. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and Cl?.
Hazard Codes:?VeryT+
Risk Statements: 25-26?
R25 :Toxic if swallowed.?
R26:Very toxic by inhalation.
Safety Statements: 22-26-28-36/37/39-45?
S22:Do not breathe dust.?
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.?
S28:After contact with skin, wash immediately with plenty of soap-suds.?
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.?
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 2811 6.1/PG 1
WGK Germany: 3
RTECS: NJ2490000
F: 10
HazardClass: 6.1(b)
PackingGroup: III


Toxicity
1. ???

orl-inf TDLo:390?μg/kg

??? PEDIAU ?? Pediatrics. 72 (1983),500.
2. ???

orl-wmn TDLo:180?μg/kg:BAH,CVS,PUL

??? AJEMEN ?? American Journal of Emergency Medicine. 7 (1989),343.
3. ???

orl-inf TDLo:390?μg/kg:NAH,CVS

??? PEDIAU ?? Pediatrics. 72 (1983),500.
4. ???

orl-wmn TDLo:126?μg/kg/4?W-I:GIT

??? BMJOAE ?? British Medical Journal. 292 (1986),174.
5. ???

orl-man TDLo:69?μg/kg:CNS,CVS

??? LANCAO ?? Lancet. 2 (1976),694.
6. ???

orl-chd TDLo:70?μg/kg:CNS,CVS,PUL

??? AJDCAI ?? American Journal of Diseases of Children. 137 (1983),171.
7. ???

orl-rat LD50:126?mg/kg

??? IYKEDH ?? Iyakuhin Kenkyu. Study of Medical Supplies. 18 (1987),366.
8. ???

ipr-rat LD50:100?mg/kg

??? IYKEDH ?? Iyakuhin Kenkyu. Study of Medical Supplies. 9 (1978),829.
9. ???

scu-rat LD50:77?mg/kg

??? IYKEDH ?? Iyakuhin Kenkyu. Study of Medical Supplies. 18 (1987),366.
10. ???

ivn-rat LD50:29?mg/kg

??? ARZNAD ?? Arzneimittel-Forschung. Drug Research. 16 (1966),1038.
11.

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