Bufalin cas no:465-21-4
Synonyms: 5b-Bufa-20,22-dienolide, 3b,14-dihydroxy- (7CI,8CI);5β-Bufa-20,22-dienolide, 3β,14-dihydroxy-;NSC 89595;Bufa-20,22-dienolide, 3,14-dihydroxy-, (3β,5β)-;3-beta,14-Dihydroxy-5-beta-bufa-20,22-dienolide;3,14-Dihydroxy-bufa-20,22-dienolide;
NameBufalin
CAS465-21-4
Synonyms5b-Bufa-20,22-dienolide, 3b,14-dihydroxy- (7CI,8CI);5β-Bufa-20,22-dienolide, 3β,14-dihydroxy-;NSC 89595;Bufa-20,22-dienolide, 3,14-dihydroxy-, (3β,5β)-;3-beta,14-Dihydroxy-5-beta-bufa-20,22-dienolide;3,14-Dihydroxy-bufa-20,22-dienolide;
Molecular FormulaC24H34O4
Molecular Weight386.52
AppearanceWhite solid.
refractive index1.593
storage temp2-8°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(a)
Hazard T+: Very toxic;
Risk R28
Safety
Hazard Codes:
T+
Risk Statements: 28
R28:Very toxic if swallowed.
Safety Statements: 28-36/37-45
S28:After contact with skin, wash immediately with plenty of soap-suds.
S36/37:Wear suitable protective clothing and gloves.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR: UN 3462 6.1/PG 2
WGK Germany: 3
RTECS: EI2962500
HazardClass: 6.1(a)
PackingGroup: II
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| cat |
LD50 |
intravenous |
140ug/kg (0.14mg/kg) |
|
"Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963Vol. -, Pg. 189, 1963. |
| cat |
LDLo |
unreported |
137ug/kg (0.137mg/kg) |
|
Pharmaceutica Acta Helvetiae. Vol. 24, Pg. 222, 1949. |
| mouse |
LD50 |
intravenous |
740ug/kg (0.74mg/kg) |
BEHAVIORAL: TREMOR
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: ANTIPSYCHOTIC |
Chemical and Pharmaceutical Bulletin. Vol. 24, Pg. 1714, 1976. |
