Benzo[a]heptalen-9(5H)-one,6,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-, (7S)- cas no:477-30-5
Synonyms: Benzo[a]heptalen-9(5H)-one,6,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-, (S)-; Colchamine (6CI,7CI);Colchicine, N-deacetyl-N-methyl- (8CI); Colchicine, N-deacetyl-N-methyl-, (-)-(7CI); (-)-Colchamine; (-)-Demecolcine; Alkaloid H 3, from Colchicum antumnale;C 12669; Ciba 12669A; Colcemid; Colchamin; Deacetyl-N-methylcolchicine;Deacetylmethylcolchicine; Demecolcin; Demecolcine; Desacetylmethylcolchicine;Desmecolcine; Kolchamin; N-Deacetyl-N-methylcolchicine;N-Desacetyl-N-methylcolchicine; N-Methyl-N-deacetylcolchicine;N-Methyl-N-desacetylcolchicine; N-Methyltri-O-methylcolchicinic acid; NSC 3096;Omain; Omaine; Reichstein's F; Santavy's substance F; Substance F
NameBenzo[a]heptalen-9(5H)-one,6,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-, (7S)-
CAS477-30-5
SynonymsBenzo[a]heptalen-9(5H)-one,6,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-, (S)-; Colchamine (6CI,7CI);Colchicine, N-deacetyl-N-methyl- (8CI); Colchicine, N-deacetyl-N-methyl-, (-)-(7CI); (-)-Colchamine; (-)-Demecolcine; Alkaloid H 3, from Colchicum antumnale;C 12669; Ciba 12669A; Colcemid; Colchamin; Deacetyl-N-methylcolchicine;Deacetylmethylcolchicine; Demecolcin; Demecolcine; Desacetylmethylcolchicine;Desmecolcine; Kolchamin; N-Deacetyl-N-methylcolchicine;N-Desacetyl-N-methylcolchicine; N-Methyl-N-deacetylcolchicine;N-Methyl-N-desacetylcolchicine; N-Methyltri-O-methylcolchicinic acid; NSC 3096;Omain; Omaine; Reichstein's F; Santavy's substance F; Substance F
EINECS(EC#)207-514-6
Molecular FormulaC21H25 N O5
Molecular Weight371.47
refractive index1.582
storage temp2-8°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1(a)
Hazard T: Toxic;
Risk R25
Safety
Poison by ingestion, intraperitoneal, parenteral, intravenous, and intramuscular routes. Human systemic effects by ingestion: (skin and appendages) hair effects. Human mutation data reported. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
Hazard Codes:
T
T+
Risk Statements:
R25 :Toxic if swallowed.
R26/27/28:Very toxic by inhalation, in contact with skin and if swallowed.
Safety Statements:
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: UN 2811 6.1/PG 2
WGK Germany: 3
RTECS: GH0800000
F:
F 8: Photosensitive.
F 10: Keep under argon.
F 23 Sensitive to air.
HazardClass: 6.1(a)
PackingGroup: II
| Organism |
Test Type |
Route |
Reported Dose (Normalized Dose) |
Effect |
Source |
| human |
TDLo |
oral |
200ug/kg (0.2mg/kg) |
skin and appendages (skin): hair: other |
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 184, 1969. |
| mouse |
LD50 |
intramuscular |
87mg/kg (87mg/kg) |
|
Journal of Medicinal Chemistry. Vol. 24, Pg. 257, 1981. |
| mouse |
LD50 |
intraperitoneal |
35mg/kg (35mg/kg) |
|
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 230, Pg. 559, 1957. |
| mouse |
LD50 |
intravenous |
56mg/kg (56mg/kg) |
behavioral: somnolence (general depressed activity) behavioral: muscle weakness gastrointestinal: "hypermotility, diarrhea"
|
Pharmacology and Toxicology. English translation of FATOAO. Vol. 20, Pg. 284, 1957. |
| mouse |
LD50 |
oral |
25530ug/kg (25.53mg/kg) |
|
National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986, |
| rat |
LD50 |
intravenous |
1700ug/kg (1.7mg/kg) |
|
Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1467, 1970. |
| rat |
LD50 |
parenteral |
1700ug/kg (1.7mg/kg) |
|
Recent Results in Cancer Research. Vol. 52, Pg. 76, 1975. |
