50-48-6|1-Propanamine,3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-Products Supply

1-Propanamine,3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl- cas no:50-48-6

Synonyms: 5H-Dibenzo[a,d]cycloheptene-D5,g-propylamine, 10,11-dihydro-N,N-dimethyl- (6CI,8CI);5-(3-Dimethylaminopropylidene)-5H-dibenzo[a,d]-10,11-dihydrocycloheptene;5-(3'-Dimethylaminopropylidene)-dibenzo-[a,d][1,4]-cycloheptadiene; 5-(g-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene;5-(g-Dimethylaminopropylidene)-5H-dibenzo(a,d)(1,4)cycloheptadiene;Adepress; Amitriprolidine; Amitriptylin; Amitriptyline; Damilen;Damitriptyline; Flavyl; MK 230; N 750; Proheptadiene; Seroten; Triptanol;Triptisol

Identification

Name1-Propanamine,3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-
CAS50-48-6
Synonyms5H-Dibenzo[a,d]cycloheptene-D5,g-propylamine, 10,11-dihydro-N,N-dimethyl- (6CI,8CI);5-(3-Dimethylaminopropylidene)-5H-dibenzo[a,d]-10,11-dihydrocycloheptene;5-(3'-Dimethylaminopropylidene)-dibenzo-[a,d][1,4]-cycloheptadiene; 5-(g-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene;5-(g-Dimethylaminopropylidene)-5H-dibenzo(a,d)(1,4)cycloheptadiene;Adepress; Amitriprolidine; Amitriptylin; Amitriptyline; Damilen;Damitriptyline; Flavyl; MK 230; N 750; Proheptadiene; Seroten; Triptanol;Triptisol
EINECS(EC#)200-041-6
Molecular FormulaC20H23 N
Molecular Weight277.44

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

HazardclassIRRITANT

Safety Data

Safety

Human poison by an unspecified route. Poison experimentally by ingestion, intraperitoneal, subcutaneous, intramuscular, and intravenous routes. Human systemic effects by ingestion and intramuscular routes: changes in sleep, headache, paresthesia, convulsions, excitement, somnolence, muscle contractions, change in heart rate, and other cardiac changes. An experimental teratogen. Other experimental reproductive effects. An antidepressant. When heated to decomposition it emits toxic fumes of NO_x.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
child	TDLo	oral	4500ug/kg (4.5mg/kg)	BEHAVIORAL: SLEEP	British Medical Journal. Vol. 3, Pg. 663, 1967.
dog	LDLo	subcutaneous	50mg/kg (50mg/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Pharmacologist. Vol. 11, Pg. 283, 1969.
guinea pig	LDLo	intravenous	35mg/kg (35mg/kg)		Drugs of the Future. Vol. 8, Pg. 949, 1983.
human	TDLo	oral	2mg/kg/3D-I (2mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CHANGES IN PSYCHOPHYSIOLOGICAL TESTS	British Journal of Clinical Pharmacology. Vol. 49, Pg. 118, 2000.
human	TDLo	oral	14mg/kg (14mg/kg)	CARDIAC: OTHER CHANGES	Proceedings of the European Society for the Study of Drug Toxicity. Vol. 6, Pg. 171, 1965.
infant	TDLo	oral	50mg/kg (50mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: CHANGE IN RATE BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)	American Journal of Diseases of Children. Vol. 130, Pg. 507, 1976.
man	LDLo	oral	29mg/kg (29mg/kg)		Human & Experimental Toxicology. Vol. 9, Pg. 257, 1990.
man	TDLo	oral	1564mg/kg/2Y- (1564mg/kg)	PERIPHERAL NERVE AND SENSATION: PARESTHESIS BEHAVIORAL: ATAXIA BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Italian Journal of Neurological Sciences. Vol. 9, Pg. 89, 1988.
man	TDLo	unreported	45mg/kg/21D (45mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) CARDIAC: CHANGE IN RATE	Lancet. Vol. 2, Pg. 1202, 1972.
mouse	LD50	intraperitoneal	48400ug/kg (48.4mg/kg)		Farmakologiya i Toksikologiya Vol. 53(4), Pg. 19, 1990.
mouse	LD50	intravenous	16mg/kg (16mg/kg)	BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Journal of Medicinal Chemistry. Vol. 17, Pg. 65, 1974.
mouse	LD50	oral	99mg/kg (99mg/kg)		Doklady Akademii Nauk SSSR. Proceedings of the Academy of Sciences of the USSR. For English translation, see DBIOAM and DKBSAS. Vol. 335, Pg. 388, 1994.
mouse	LD50	subcutaneous	100mg/kg (100mg/kg)		United States Patent Document. Vol. #4605673,
mouse	LD50	unreported	80mg/kg (80mg/kg)	AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"	Journal of Medicinal Chemistry. Vol. 10, Pg. 418, 1967.
rabbit	LD50	intraperitoneal	58700ug/kg (58.7mg/kg)	LUNGS, THORAX, OR RESPIRATION: CYANOSIS	Journal of Toxicology, Clinical Toxicology. Vol. 19, Pg. 321, 1982.
rabbit	LD50	intravenous	8600ug/kg (8.6mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 863, 1965.
rat	LD50	intraperitoneal	72mg/kg (72mg/kg)		Polish Journal of Pharmacology and Pharmacy. Vol. 27, Pg. 503, 1975.
rat	LD50	oral	320mg/kg (320mg/kg)	BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS BEHAVIORAL: ATAXIA	Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 863, 1965.
women	TDLo	intramuscular	240ug/kg/36H- (0.24mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Lancet. Vol. 1, Pg. 390, 1968.
women	TDLo	oral	13500ug/kg/3D (13.5mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT	Lancet. Vol. 1, Pg. 390, 1968.
women	TDLo	oral	16800ug/kg/2W (16.8mg/kg)	PERIPHERAL NERVE AND SENSATION: PARESTHESIS BEHAVIORAL: HEADACHE	Lancet. Vol. 1, Pg. 426, 1968.
women	TDLo	oral	18500ug/kg (18.5mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES	Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 35, Pg. 795, 1993.
women	TDLo	oral	60mg/kg (60mg/kg)	CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION) CARDIAC: CHANGE IN RATE VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	Journal of Toxicology, Clinical Toxicology. Vol. 19, Pg. 67, 1982.
women	TDLo	oral	84mg/kg (84mg/kg)	CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE	Japanese Journal of Toxicology. Vol. 5, Pg. 69, 1992.

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1-Propanamine,3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl- cas no:50-48-6

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