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Home > products > 1-Propanamine,3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-

1-Propanamine,3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl- cas no:50-48-6

Synonyms: 5H-Dibenzo[a,d]cycloheptene-D5,g-propylamine, 10,11-dihydro-N,N-dimethyl- (6CI,8CI);5-(3-Dimethylaminopropylidene)-5H-dibenzo[a,d]-10,11-dihydrocycloheptene;5-(3'-Dimethylaminopropylidene)-dibenzo-[a,d][1,4]-cycloheptadiene; 5-(g-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene;5-(g-Dimethylaminopropylidene)-5H-dibenzo(a,d)(1,4)cycloheptadiene;Adepress; Amitriprolidine; Amitriptylin; Amitriptyline; Damilen;Damitriptyline; Flavyl; MK 230; N 750; Proheptadiene; Seroten; Triptanol;Triptisol

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Identification
Name1-Propanamine,3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-
CAS50-48-6
Synonyms5H-Dibenzo[a,d]cycloheptene-D5,g-propylamine, 10,11-dihydro-N,N-dimethyl- (6CI,8CI);5-(3-Dimethylaminopropylidene)-5H-dibenzo[a,d]-10,11-dihydrocycloheptene;5-(3'-Dimethylaminopropylidene)-dibenzo-[a,d][1,4]-cycloheptadiene; 5-(g-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene;5-(g-Dimethylaminopropylidene)-5H-dibenzo(a,d)(1,4)cycloheptadiene;Adepress; Amitriprolidine; Amitriptylin; Amitriptyline; Damilen;Damitriptyline; Flavyl; MK 230; N 750; Proheptadiene; Seroten; Triptanol;Triptisol
EINECS(EC#)200-041-6
Molecular FormulaC20H23 N
Molecular Weight277.44
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
HazardclassIRRITANT
Safety Data

Safety

Human poison by an unspecified route. Poison experimentally by ingestion, intraperitoneal, subcutaneous, intramuscular, and intravenous routes. Human systemic effects by ingestion and intramuscular routes: changes in sleep, headache, paresthesia, convulsions, excitement, somnolence, muscle contractions, change in heart rate, and other cardiac changes. An experimental teratogen. Other experimental reproductive effects. An antidepressant. When heated to decomposition it emits toxic fumes of NOx.


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 4500ug/kg (4.5mg/kg) BEHAVIORAL: SLEEP British Medical Journal. Vol. 3, Pg. 663, 1967.
dog LDLo subcutaneous 50mg/kg (50mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Pharmacologist. Vol. 11, Pg. 283, 1969.
guinea pig LDLo intravenous 35mg/kg (35mg/kg)   Drugs of the Future. Vol. 8, Pg. 949, 1983.
human TDLo oral 2mg/kg/3D-I (2mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: CHANGES IN PSYCHOPHYSIOLOGICAL TESTS		 British Journal of Clinical Pharmacology. Vol. 49, Pg. 118, 2000.
human TDLo oral 14mg/kg (14mg/kg) CARDIAC: OTHER CHANGES Proceedings of the European Society for the Study of Drug Toxicity. Vol. 6, Pg. 171, 1965.
infant TDLo oral 50mg/kg (50mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: CHANGE IN RATE

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)		 American Journal of Diseases of Children. Vol. 130, Pg. 507, 1976.
man LDLo oral 29mg/kg (29mg/kg)   Human & Experimental Toxicology. Vol. 9, Pg. 257, 1990.
man TDLo oral 1564mg/kg/2Y- (1564mg/kg) PERIPHERAL NERVE AND SENSATION: PARESTHESIS

BEHAVIORAL: ATAXIA

BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)		 Italian Journal of Neurological Sciences. Vol. 9, Pg. 89, 1988.
man TDLo unreported 45mg/kg/21D (45mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

CARDIAC: CHANGE IN RATE		 Lancet. Vol. 2, Pg. 1202, 1972.
mouse LD50 intraperitoneal 48400ug/kg (48.4mg/kg)   Farmakologiya i Toksikologiya Vol. 53(4), Pg. 19, 1990.
mouse LD50 intravenous 16mg/kg (16mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Journal of Medicinal Chemistry. Vol. 17, Pg. 65, 1974.
mouse LD50 oral 99mg/kg (99mg/kg)   Doklady Akademii Nauk SSSR. Proceedings of the Academy of Sciences of the USSR. For English translation, see DBIOAM and DKBSAS. Vol. 335, Pg. 388, 1994.
mouse LD50 subcutaneous 100mg/kg (100mg/kg)   United States Patent Document. Vol. #4605673,
mouse LD50 unreported 80mg/kg (80mg/kg) AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)" Journal of Medicinal Chemistry. Vol. 10, Pg. 418, 1967.
rabbit LD50 intraperitoneal 58700ug/kg (58.7mg/kg) LUNGS, THORAX, OR RESPIRATION: CYANOSIS Journal of Toxicology, Clinical Toxicology. Vol. 19, Pg. 321, 1982.
rabbit LD50 intravenous 8600ug/kg (8.6mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 863, 1965.
rat LD50 intraperitoneal 72mg/kg (72mg/kg)   Polish Journal of Pharmacology and Pharmacy. Vol. 27, Pg. 503, 1975.
rat LD50 oral 320mg/kg (320mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS

BEHAVIORAL: ATAXIA		 Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 863, 1965.
women TDLo intramuscular 240ug/kg/36H- (0.24mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Lancet. Vol. 1, Pg. 390, 1968.
women TDLo oral 13500ug/kg/3D (13.5mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: EXCITEMENT		 Lancet. Vol. 1, Pg. 390, 1968.
women TDLo oral 16800ug/kg/2W (16.8mg/kg) PERIPHERAL NERVE AND SENSATION: PARESTHESIS

BEHAVIORAL: HEADACHE		 Lancet. Vol. 1, Pg. 426, 1968.
women TDLo oral 18500ug/kg (18.5mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES		 Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 35, Pg. 795, 1993.
women TDLo oral 60mg/kg (60mg/kg) CARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)

CARDIAC: CHANGE IN RATE

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION		 Journal of Toxicology, Clinical Toxicology. Vol. 19, Pg. 67, 1982.
women TDLo oral 84mg/kg (84mg/kg) CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE Japanese Journal of Toxicology. Vol. 5, Pg. 69, 1992.

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