508-75-8|Card-20(22)-enolide,3-[(6-deoxy-a-L-mannopyranosyl)oxy]-5,14-dihydroxy-19-oxo-,(3b,5b)-Products Supply

Card-20(22)-enolide,3-[(6-deoxy-a-L-mannopyranosyl)oxy]-5,14-dihydroxy-19-oxo-,(3b,5b)- cas no:508-75-8

Synonyms: Convallatoxin(6CI,7CI,8CI); Convallaotoxin; Convallaton; Convallatoxine; Convallatoxoside;Convallotoxin; Corglycon; Corglycone; Corglykon; Korglykon; NSC 407808;Strophanthidin a-L-rhamnoside

Identification

NameCard-20(22)-enolide,3-[(6-deoxy-a-L-mannopyranosyl)oxy]-5,14-dihydroxy-19-oxo-,(3b,5b)-
CAS508-75-8
SynonymsConvallatoxin(6CI,7CI,8CI); Convallaotoxin; Convallaton; Convallatoxine; Convallatoxoside;Convallotoxin; Corglycon; Corglycone; Corglykon; Korglykon; NSC 407808;Strophanthidin a-L-rhamnoside
EINECS(EC#)208-086-3
Molecular FormulaC29H42 O10
Molecular Weight550.71

Chemical Properties

refractive index1.622

Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)

Hazardclass6.1(b)

Safety Data

Safety

Poison by subcutaneous, intravenous, intraduodenal, intraperitoneal, and possibly other routes. When heated to decomposition it emits acrid smoke and fumes.

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LD50	intraduodenal	2100ug/kg (2.1mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958.
cat	LD50	intraperitoneal	180ug/kg (0.18mg/kg)		Acta Biologica et Medica Germanica. Vol. 12, Pg. 434, 1964.
cat	LD50	intravenous	74ug/kg (0.074mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 74, Pg. 223, 1942.
cat	LD50	oral	3650ug/kg (3.65mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958.
cat	LDLo	unreported	50ug/kg (0.05mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 148, Pg. 471, 1964.
frog	LD50	subcutaneous	440ug/kg (0.44mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958.
frog	LDLo	intravenous	300ug/kg (0.3mg/kg)		Merck Index. Vol. 10, Pg. 357, 1983.
guinea pig	LD50	intraperitoneal	200ug/kg (0.2mg/kg)		Acta Biologica et Medica Germanica. Vol. 12, Pg. 434, 1964.
guinea pig	LD50	intravenous	185ug/kg (0.185mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958.
guinea pig	LD50	oral	> 50mg/kg (50mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958.
guinea pig	LD95	intraduodenal	10490ug/kg (10.49mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958.
monkey	LDLo	intravenous	90ug/kg (0.09mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 13, Pg. 412, 1963.
mouse	LD50	intraperitoneal	10mg/kg (10mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 165, 1965.
mouse	LD50	intravenous	1mg/kg (1mg/kg)		U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00462,
mouse	LD50	oral	> 2gm/kg (2000mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 8, Pg. 557, 1958.
mouse	LD50	subcutaneous	15mg/kg (15mg/kg)		Farmakologiya i Toksikologiya Vol. 44, Pg. 342, 1981.
pig	LDLo	intraduodenal	3170ug/kg (3.17mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 229, 1970.
pig	LDLo	intravenous	50ug/kg (0.05mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 229, 1970.
pigeon	LDLo	intravenous	248ug/kg (0.248mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 13, Pg. 412, 1963.
rat	LD50	intravenous	15200ug/kg (15.2mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Arzneimittel-Forschung. Drug Research. Vol. 11, Pg. 848, 1961.

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Card-20(22)-enolide,3-[(6-deoxy-a-L-mannopyranosyl)oxy]-5,14-dihydroxy-19-oxo-,(3b,5b)- cas no:508-75-8

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