54-05-7|1,4-Pentanediamine,N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-Products Supply

1,4-Pentanediamine,N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl- cas no:54-05-7

Synonyms: Quinoline,7-chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]- (8CI);(?à)-Chloroquine;7-Chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]quinoline;Aralen;Artrichin;Bipiquin;Capquin;Chloraquine;Chlorochin;Chloroquine;NSC187208;RP 3377;Reumachlor;Ronaquine;ST 121;ST 121 (pharmaceutical);

Identification

Name1,4-Pentanediamine,N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-
CAS54-05-7
SynonymsQuinoline,7-chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]- (8CI);(?à)-Chloroquine;7-Chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]quinoline;Aralen;Artrichin;Bipiquin;Capquin;Chloraquine;Chlorochin;Chloroquine;NSC187208;RP 3377;Reumachlor;Ronaquine;ST 121;ST 121 (pharmaceutical);
EINECS(EC#)200-191-2
Molecular FormulaC18H26 Cl N3
Molecular Weight319.92

Chemical Properties

AppearanceWhite powder
refractive index1.592

Safety Data

Safety Poison by ingestion, intraperitoneal, intravenous, intramuscular, and subcutaneous routes. Human systemic effects by ingestion: heart rate changes, nausea or vomiting. Human teratogenic effects by an unspecified route include developmental abnormalities of the urogenital system, eyes and ears, other unspecified areas, and postnatal effects. Human reproductive effects by an unspecified route: terminates pregnancy. Human mutation data reported. Questionable carcinogen. An antimalarial agent. When heated to decomposition it emits very toxic fumes of Cl− and NOx.

Toxicity

child	LDLo	oral	37593ug/kg (37.593mg/kg)	BRAIN AND COVERINGS: OTHER DEGENERATIVE CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: CHANGE IN RATE	Annals of Emergency Medicine. Vol. 19, Pg. 47, 1990.
human	LDLo	oral	20mg/kg (20mg/kg)	SENSE ORGANS AND SPECIAL SENSES: DIPLOPIA: EYE BEHAVIORAL: COMA VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION	Journal Europeen de Toxicologie. Vol. 6, Pg. 86, 1973.
man	LDLo	oral	86mg/kg (86mg/kg)	CARDIAC: CHANGE IN RATE CARDIAC: OTHER CHANGES GASTROINTESTINAL: NAUSEA OR VOMITING	New England Journal of Medicine. Vol. 318, Pg. 1, 1988.
mouse	LD50	intramuscular	71mg/kg (71mg/kg)		Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. Vol. 4, Pg. 69, 1983.
mouse	LD50	intraperitoneal	66mg/kg (66mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 1219, 1982.
mouse	LD50	intravenous	21600ug/kg (21.6mg/kg)		Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. Vol. 4, Pg. 69, 1983.
mouse	LD50	oral	311mg/kg (311mg/kg)	BEHAVIORAL: TREMOR LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Oyo Yakuri. Pharmacometrics. Vol. 7, Pg. 753, 1973.
mouse	LD50	subcutaneous	150mg/kg (150mg/kg)		Journal Europeen de Toxicologie. Vol. 6, Pg. 86, 1973.
rabbit	LD50	intravenous	8mg/kg (8mg/kg)		Therapie. Vol. 25, Pg. 823, 1970.
rabbit	LD50	subcutaneous	75mg/kg (75mg/kg)		Journal Europeen de Toxicologie. Vol. 6, Pg. 86, 1973.
rabbit	LDLo	intramuscular	20mg/kg (20mg/kg)		Yaoxue Xuebao. Acta Pharmaceutica Sinica. Pharmaceutical Journal. Vol. 15, Pg. 630, 1980.
rat	LD50	intraperitoneal	102mg/kg (102mg/kg)	GASTROINTESTINAL: OTHER CHANGES	Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 13, Pg. 401, 1975.
rat	LD50	intravenous	60mg/kg (60mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 163, Pg. 38, 1966.
rat	LD50	oral	330mg/kg (330mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA	Journal of Toxicology, Clinical Toxicology. Vol. 20, Pg. 271, 1983.
rat	LD50	subcutaneous	190mg/kg (190mg/kg)		Archives Internationales de Pharmacodynamie et de Therapie. Vol. 163, Pg. 38, 1966.
women	LDLo	oral	110mg/kg (110mg/kg)	CARDIAC: CHANGE IN RATE CARDIAC: OTHER CHANGES GASTROINTESTINAL: NAUSEA OR VOMITING	New England Journal of Medicine. Vol. 318, Pg. 1, 1988.
women	LDLo	oral	180mg/kg (180mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	Medical Journal of Australia. Vol. 160, Pg. 231, 1994.
women	TDLo	oral	24mg/kg/12D-I (24mg/kg)	BRAIN AND COVERINGS: CHANGES IN SURFACE EEG BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)	Annals of Internal Medicine. Vol. 123, Pg. 76, 1995.
women	TDLo	oral	3600mg/kg/3Y (3600mg/kg)	SENSE ORGANS AND SPECIAL SENSES: VISUAL FIELD CHANGES: EYE GASTROINTESTINAL: OTHER CHANGES	Tropical and Geographical Medicine. Vol. 32, Pg. 216, 1980.

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IOL Chemicals and Pharmaceuticals Limited: Tel:+91-(161)-2225531; Address: 85, Industrial Area A, Ludhiana, Punjab 141 003,

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Tianjin Harmony Technology Development Co., Ltd.: Tel:; Address: Room 601 of BokeBuilding, 100 Fukang Road, Tianjin, China

Hangzhou Dayangchem Co., Ltd.: Tel:86-571-88938639; Address: 9/F Unit 2 ChangdiTorch Building, 259 #WenSan Road

Zhejiang Haiqiang Chemical Co.,Ltd.: Tel:86-571-86960370; Address: 5/F, Around Town North Road,No. 10, Hangzhou, Zhejiang,China

Andexin industrial Co.,Limited: Tel:86-411-39074598; Address: No.98,Shengli road,,Jinzhou district,

1,4-Pentanediamine,N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl- cas no:54-05-7

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