Chlorotetracycline cas no:57-62-5
Synonyms: 2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-(7CI,8CI);2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,[4S-(4a,4aa,5aa,6b,12aa)]-;Aureomicina;Aureomycin;Aureomykoin;Aurofac;Aureocina;A-Mycin;Acronize;7-Chlorotetracycline;7-Chlortetracycline;Tri-chlortetracycline;Acronize PD;Chrysomykine;Chlortetracycline;Centraureo;Chlorocyclinum;
NameChlorotetracycline
CAS57-62-5
Synonyms2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-(7CI,8CI);2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,[4S-(4a,4aa,5aa,6b,12aa)]-;Aureomicina;Aureomycin;Aureomykoin;Aurofac;Aureocina;A-Mycin;Acronize;7-Chlorotetracycline;7-Chlortetracycline;Tri-chlortetracycline;Acronize PD;Chrysomykine;Chlortetracycline;Centraureo;Chlorocyclinum;
EINECS(EC#)200-341-7
Molecular FormulaC22H23ClN2O8
Molecular Weight478.88
AppearanceGolden yellow crystal powder
refractive index1.745
storage temp2-8°C
Hazard Xn
Risk R22
Safety
Hazard Codes:? Xn
Risk Statements:? 22
22:?Chlorotetracycline (57-62-5) is harmful if swallowed?
RTECS:? QI7750000
?
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Organism
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Test Type
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Route
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Reported Dose (Normalized Dose)
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Effect
|
Source
|
|
dog
|
LD50
|
intravenous
|
150mg/kg (150mg/kg)
|
?
|
"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 52, 1959.
|
|
dog
|
LD50
|
oral
|
750mg/kg (750mg/kg)
|
?
|
Antimicrobial Agents Annual. Vol. -, Pg. 595, 1960.
|
|
guinea pig
|
LDLo
|
intraperitoneal
|
1800mg/kg (1800mg/kg)
|
?
|
Antibiotiki. Vol. 20, Pg. 793, 1975.
|
|
mouse
|
LD50
|
intracrebral
|
48mg/kg (48mg/kg)
|
behavioral: "hallucinations, distorted perceptions"
behavioral: excitement
musculoskeletal: changes in teeth and supporting structures
|
Chemotherapy Vol. 26, Pg. 196, 1980.
|
|
mouse
|
LD50
|
intravenous
|
134mg/kg (134mg/kg)
|
?
|
Antibiotics and Chemotherapy Vol. 6, Pg. 623, 1956.
|
|
mouse
|
LD50
|
oral
|
1500mg/kg (1500mg/kg)
|
?
|
Antimicrobial Agents Annual. Vol. -, Pg. 595, 1960.
|
|
mouse
|
LDLo
|
intraperitoneal
|
192mg/kg (192mg/kg)
|
?
|
Compilation of LD50 Values of New Drugs.
|
|
mouse
|
LDLo
|
subcutaneous
|
3gm/kg (3000mg/kg)
|
?
|
Antibiotics and Chemotherapy Vol. 6, Pg. 623, 1956.
|
|
rat
|
LD50
|
intravenous
|
118mg/kg (118mg/kg)
|
?
|
Antibiotics and Chemotherapy Vol. 6, Pg. 623, 1956.
|
|
rat
|
LDLo
|
intraperitoneal
|
335mg/kg (335mg/kg)
|
?
|
Compilation of LD50 Values of New Drugs.
|
|
rat
|
LDLo
|
oral
|
3gm/kg (3000mg/kg)
|
?
|
Journal of Agricultural and Food Chemistry. Vol. 17, Pg. 497, 1969.
|
?
