58-28-6|10,11-Dihydro-5-(3-(methylamino)prop-yl)-5h-dibenz(b,f)azepine hydro-chlorideProducts Supply

10,11-Dihydro-5-(3-(methylamino)prop-yl)-5h-dibenz(b,f)azepine hydro-chloride cas no:58-28-6

Synonyms: 5H-Dibenz[b,f]azepine,10,11-dihydro-5-[3-(methylamino)propyl]-, monohydrochloride (8CI);5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N-methyl-, monohydrochloride(9CI);10,11-Dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f]azepinemonohydrochloride;5-[3-(Methylamino)propyl]-5H-dibenz[b,f]azepinehydrochloride;DMI hydrochloride;Demethylimipramine hydrochloride;Desimipramine-hydrochloride;Desipramine hydrochloride;Desipraminemonohydrochloride;Desmethylimipramine chloride;Desmethylimipraminemonohydrochloride;Desmethylimipramine-hydrochloride;GMI;JB8181;N-(g-Methylaminopropyl)iminodibenzylhydrochloride;Norpramin;Nortrimil;Pertofran;Pertofrane;

Identification

Name10,11-Dihydro-5-(3-(methylamino)prop-yl)-5h-dibenz(b,f)azepine hydro-chloride
CAS58-28-6
Synonyms5H-Dibenz[b,f]azepine,10,11-dihydro-5-[3-(methylamino)propyl]-, monohydrochloride (8CI);5H-Dibenz[b,f]azepine-5-propanamine, 10,11-dihydro-N-methyl-, monohydrochloride(9CI);10,11-Dihydro-5-[3-(methylamino)propyl]-5H-dibenz[b,f]azepinemonohydrochloride;5-[3-(Methylamino)propyl]-5H-dibenz[b,f]azepinehydrochloride;DMI hydrochloride;Demethylimipramine hydrochloride;Desimipramine-hydrochloride;Desipramine hydrochloride;Desipraminemonohydrochloride;Desmethylimipramine chloride;Desmethylimipraminemonohydrochloride;Desmethylimipramine-hydrochloride;GMI;JB8181;N-(g-Methylaminopropyl)iminodibenzylhydrochloride;Norpramin;Nortrimil;Pertofran;Pertofrane;
EINECS(EC#)200-373-1
Molecular FormulaC₁₈H₂₃ClN₂
Molecular Weight266.38068

Chemical Properties

Appearancewhite to off-white powder
storage temp2-8°C

Safety Data

Hazard Xn: Harmful;F: Flammable;T: Toxic;
Risk R22;R36/37/38;R42/43;R48/23/24/25;R11
Safety

Poison by ingestion, intraperitoneal, subcutaneous, and intravenous routes. Human systemic effects by ingestion: decreased urine volume, sodium level changes, chlorine level changes. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of NO_x and HCl.
Hazard Codes: Harmful Xn, Toxic T, Flammable F
Risk Statements: 22-36/37/38-42/43-48/23/24/25-23/24/25-11
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.
R42/43:May cause sensitization by inhalation and skin contact.
R48:Danger of serious damage to health by prolonged exposure.
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed.
R11:Highly flammable.
Safety Statements: 7-16-36/37-45-26-24-22
S7:Keep container tightly closed.
S16:Keep away from sources of ignition.
S36/37:Wear suitable protective clothing and gloves.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S24:Avoid contact with skin.
S22:Do not breathe dust.
RIDADR: UN 1230 3/PG 2
WGK Germany: 3
RTECS: HO0525000

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	25mg/kg (25mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 70, 1972.
guinea pig	LDLo	intravenous	55mg/kg (55mg/kg)	CARDIAC: OTHER CHANGES	Therapie. Vol. 20, Pg. 67, 1965.
man	TDLo	oral	490ug/kg (0.49mg/kg)	BEHAVIORAL: SLEEP	Journal of Clinical Psychiatry. Vol. 47, Pg. 210, 1986.
man	TDLo	oral	5mg/kg/5D-I (5mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: TOXIC PSYCHOSIS	American Journal of Psychiatry. Vol. 142, Pg. 386, 1985.
mouse	LD50	intraperitoneal	88mg/kg (88mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 70, 1972.
mouse	LD50	intravenous	37mg/kg (37mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: REGIDITY	International Journal of Neuropharmacology. Vol. 4, Pg. 111, 1965.
mouse	LD50	oral	315mg/kg (315mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 70, 1972.
rat	LD50	intraperitoneal	55mg/kg (55mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 70, 1972.
rat	LD50	intravenous	19mg/kg (19mg/kg)		"Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 70, 1972.
rat	LD50	oral	871mg/kg (871mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 1411, 1983.
women	TDLo	oral	14mg/kg/1W-I (14mg/kg)	KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED	Journal of Clinical Psychiatry. Vol. 44, Pg. 153, 1983.
women	TDLo	oral	36mg/kg/6D-I (36mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" GASTROINTESTINAL: DECREASED MOTILITY OR CONSTIPATION	Journal of Clinical Psychiatry. Vol. 53, Pg. 160, 1992.
women	TDLo	oral	45mg/kg (45mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: ACUTE PULMONARY EDEMA	Annals of Pharmacotherpy. Vol. 27, Pg. 572, 1993.
women	TDLo	oral	70mg/kg/4W-I (70mg/kg)	BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" BEHAVIORAL: TOXIC PSYCHOSIS	American Journal of Psychiatry. Vol. 142, Pg. 386, 1985.

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10,11-Dihydro-5-(3-(methylamino)prop-yl)-5h-dibenz(b,f)azepine hydro-chloride cas no:58-28-6

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