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Ethanaminium,2-(acetyloxy)-N,N,N-trimethyl-, chloride (1:1) cas no:60-31-1

Synonyms: Cholineacetate (ester), chloride (8CI);Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-,chloride (9CI);(2-Hydroxyethyl)trimethylammonium chloride acetate;2-Acetoxyethyltrimethylammonium chloride;ACh chloride;Acecholin;Acecoline;Acetylcholinium chloride;Arterocoline;Miochol;O-Acetylcholine chloride;Ovisot;Trimethyl(2-acetoxyethyl)ammonium chloride;

Identification
NameEthanaminium,2-(acetyloxy)-N,N,N-trimethyl-, chloride (1:1)
CAS60-31-1
SynonymsCholineacetate (ester), chloride (8CI);Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-,chloride (9CI);(2-Hydroxyethyl)trimethylammonium chloride acetate;2-Acetoxyethyltrimethylammonium chloride;ACh chloride;Acecholin;Acecoline;Acetylcholinium chloride;Arterocoline;Miochol;O-Acetylcholine chloride;Ovisot;Trimethyl(2-acetoxyethyl)ammonium chloride;
EINECS(EC#)200-468-8
Molecular FormulaC7H16NO2.Cl
Molecular Weight181.66
Chemical Properties
AppearanceWhite crystalline powder
storage temp0-6°C
Sensitive Hygroscopic
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
HazardclassIRRITANT
Safety Data

Hazard Xi:Irritant
Risk R36/37/38
Safety

Poison by subcutaneous, intravenous, and parenteral routes. Moderately toxic by ingestion. When heated to decomposition it emits very toxic fumes of NOx and Cl?. A cholinergic agent. See also CHOLINE ACETATE (ESTER).
Safety Information of 2-Acetoxyethyltrimethylammonium chloride (CAS NO.60-31-1):
Hazard Codes: Xi
Risk Statements: 36/37/38
36:? Irritating to the eyes?
37:? Irritating to the respiratory system?
38:? Irritating to the skin??
Safety Statements: 26-37/39-36
26:? In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:? Wear suitable protective clothing??
37:? Wear suitable gloves?
39:? Wear eye/face protection


HS Code 29379000

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
frog LDLo parenteral 200mg/kg (200mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: STIFFNESS

CARDIAC: OTHER CHANGES
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 166, Pg. 437, 1932.
frog LDLo unreported 500mg/kg (500mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 164, Pg. 346, 1932.
guinea pig LD50 intravenous 7700ug/kg (7.7mg/kg) ? Archives Internationales de Pharmacodynamie et de Therapie. Vol. 170, Pg. 461, 1967.
mouse LD50 intraperitoneal 15300ug/kg (15.3mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Farmakologiya i Toksikologiya Vol. 20(4), Pg. 32, 1957.
mouse LD50 intravenous 10mg/kg (10mg/kg) PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE Journal of Pharmacology and Experimental Therapeutics. Vol. 119, Pg. 541, 1957.
mouse LD50 oral 3gm/kg (3000mg/kg) ? Journal of Pharmacology and Experimental Therapeutics. Vol. 58, Pg. 337, 1936.
mouse LD50 subcutaneous 170mg/kg (170mg/kg) ? Journal of Pharmacology and Experimental Therapeutics. Vol. 58, Pg. 337, 1936.
rat LD50 intravenous 22mg/kg (22mg/kg) ? Journal of Pharmacology and Experimental Therapeutics. Vol. 58, Pg. 337, 1936.
rat LD50 oral 2500mg/kg (2500mg/kg) ? Journal of Pharmacology and Experimental Therapeutics. Vol. 58, Pg. 337, 1936.
rat LD50 subcutaneous 250mg/kg (250mg/kg) ? Journal of Pharmacology and Experimental Therapeutics. Vol. 58, Pg. 337, 1936.

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