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(o-BROMOBENZYL)ETHYLDIMETHYL AMMONIUM-p-TOLUENESULFONATE cas no:61-75-6

Synonyms: bretyliumtosilate;2bromobenzylethyldimethylammoniumtoluene4sulphonate;2'Deoxy2',2'difluorocytidine;Bretylol

Identification
Name(o-BROMOBENZYL)ETHYLDIMETHYL AMMONIUM-p-TOLUENESULFONATE
CAS61-75-6
Synonymsbretyliumtosilate;2bromobenzylethyldimethylammoniumtoluene4sulphonate;2'Deoxy2',2'difluorocytidine;Bretylol
EINECS(EC#)200-516-8
Molecular FormulaC11H17BrN•C7H7O3S
Molecular Weight414.36
Safety Data

Hazard Xn
Risk 20/21/22
Safety

A poison by ingestion, intraperitoneal, subcutaneous, intravenous, and intramuscular routes. An anti-adrenergic agent and antiarrhythmic cardiac depressant. When heated to decomposition it emits very toxic fumes of SOx, NH3, NOx, and Br. See also SULFONATES.
Hazard Codes HarmfulXn
Risk Statements 20/21/22
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements 36
S36:Wear suitable protective clothing.
RTECS BO9450000


Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intramuscular 100mg/kg (100mg/kg)   Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 148, 1979.
dog LD50 intravenous 43mg/kg (43mg/kg)   Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 148, 1979.
mouse LD50 intramuscular 64mg/kg (64mg/kg)   Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 148, 1979.
mouse LD50 intraperitoneal 39mg/kg (39mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 155, Pg. 69, 1965.
mouse LD50 intravenous 14mg/kg (14mg/kg)   Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 148, 1979.
mouse LD50 oral 400mg/kg (400mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 14, Pg. 536, 1959.
mouse LD50 subcutaneous 72mg/kg (72mg/kg)   British Journal of Pharmacology and Chemotherapy. Vol. 14, Pg. 536, 1959.
rabbit LD50 intramuscular 160mg/kg (160mg/kg)   Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 148, 1979.
rabbit LD50 intravenous 30mg/kg (30mg/kg)   Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 148, 1979.
rat LD50 intramuscular 84mg/kg (84mg/kg)   Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 148, 1979.
rat LD50 intraperitoneal 57mg/kg (57mg/kg)   Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 21, Pg. 256, 1980.
rat LD50 intravenous 17mg/kg (17mg/kg)   Pharmacological and Biochemical Properties of Drug Substances. Vol. 2, Pg. 148, 1979.
women TDLo intravenous 81500ug/kg/15 (81.5mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY)

BEHAVIORAL: COMA

VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
American Journal of Emergency Medicine. Vol. 13, Pg. 177, 1995.

supplier list

Tianjin Harmony Technology Development Co., Ltd.
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Address: Room 601 of BokeBuilding, 100 Fukang Road, Tianjin, China
Hangzhou Tino Bio-tech Co., Ltd.
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Address: Room 311, NO.3 Building Xixi Fashion, NO.499 Wensan West Road, Xihu District, Hangzhou, China
TopChem Laboratories Limited
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Address: 70 Western Parkway Business Park, Ballymount Drive, Dublin 12,
Siegfried (USA), Inc.
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Address: 33 Industrial Park Road, Pennsville, New Jersey 8070,
Quilin Chemicals Development, Inc.
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Address: 6956 Country Lakes Circle, Sarasota, Florida 34243,
Fox Chemicals GmbH
Tel:+49-(7240)-927151
Address: Bockstalstr.10 A, Pfinztal D-76327,
Haihang Industry Co., Ltd.
Tel:+86-(531)-88032799
Address: 2/F, East Tower, Bldg 12, No. 2 Qilihe Road, Jinan 250100,
Manus Aktteva
Tel:+91-(79)-65123395
Address: 303, 3rd Floor, Royale Manor, Law Garden, Dhulia Kot Road, Ellisbridge, Ahmedabad, Gujarat 380006,
Kouting Chemical Co.,Ltd
Tel:+86-(21)-58116473
Address: Hunan Road, Pudong New District, Shanghai, Shanghai 201318,
Hotechem Shanghai Co., Ltd
Tel:+86-21-54420853;13120882795;+86-21-34621078
Address: Room 209,Suite 2,No.2715 Longwu Road
shanghai sphchem co.,ltd
Tel:+86-21-56491756 13512199871
Address: NO.133, Wuye, Yangxin Road ,Shanghai China
Jinan Haohua Industry Co., Ltd.
Tel:0086-531-58773055
Address: No.59 Gongye South RD
Boc Sciences
Tel:1-631-5046093
Address: 45-16 Ramsey Road Shirley, NY 11967, USA
Hangzhou Dayangchem Co., Ltd.
Tel:86-571-88938639
Address: 9/F Unit 2 ChangdiTorch Building, 259 #WenSan Road
Nanjing Chemlin Chemical Co., Ltd.
Tel:86-25-83697070
Address: Rm.902 Longyin Plaza, No. 217 Zhongshan Rd.(N) Nanjing 210009,China

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