637-07-0|Propanoic acid,2-(4-chlorophenoxy)-2-methyl-, ethyl esterProducts Supply

Propanoic acid,2-(4-chlorophenoxy)-2-methyl-, ethyl ester cas no:637-07-0

Synonyms: Propionicacid, 2-(p-chlorophenoxy)-2-methyl-, ethyl ester (6CI,8CI);2-(4-Chlorophenoxy)isobutyric acid ethyl ester;2-(p-Chlorophenoxy)-2-methylpropionic acid ethyl ester;AY 61123;Abitrate;Amotril;Anparton;Apolan;Arteriosan;Artevil;Ateculon;Ateriosan;Atheropront;Atromid S;Atromidin;Azionyl;Bioscleran;CPIB;Cartagyl;Claripex;Claripex CPIB;Clobren SF;Clofibrat;Clofibrate;Clofinit;ECPIB;EPIB;Ethyl 2-(4-chlorophenoxy)-2-methylpropionate;Ethyl2-(4-chlorophenoxy)isobutyrate;Ethyl 2-(p-chlorophenoxy)-2-methylpropionate;Ethyl 2-(p-chlorophenoxy)isobutyrate;Ethyl clofibrate;Ethyl p-chlorophenoxyisobutyrate;Ethyl a-(4-chlorophenoxy)-a-methylpropionate;Ethyl a-(4-chlorophenoxy)isobutyrate;Ethyl a-(p-chlorophenoxy)-a-methylpropionate;Ethyl a-(p-chlorophenoxy)isobutyrate;Hyclorate;ICI 28257;Lipavil;Lipavlon;Lipomid;Liprinal;Miscleron;Misclerone;NSC 79389;Neo-Atromid;Normet;Normolipol;Recolip;Regelan;Serotinex;Sklerepmexe;Sklero-Tablinene;Sklerolip;Skleromexe;Ticlobran;Xyduril;p-Chlorophenoxyisobutyric acid ethyl ester;

Identification

NamePropanoic acid,2-(4-chlorophenoxy)-2-methyl-, ethyl ester
CAS637-07-0
SynonymsPropionicacid, 2-(p-chlorophenoxy)-2-methyl-, ethyl ester (6CI,8CI);2-(4-Chlorophenoxy)isobutyric acid ethyl ester;2-(p-Chlorophenoxy)-2-methylpropionic acid ethyl ester;AY 61123;Abitrate;Amotril;Anparton;Apolan;Arteriosan;Artevil;Ateculon;Ateriosan;Atheropront;Atromid S;Atromidin;Azionyl;Bioscleran;CPIB;Cartagyl;Claripex;Claripex CPIB;Clobren SF;Clofibrat;Clofibrate;Clofinit;ECPIB;EPIB;Ethyl 2-(4-chlorophenoxy)-2-methylpropionate;Ethyl2-(4-chlorophenoxy)isobutyrate;Ethyl 2-(p-chlorophenoxy)-2-methylpropionate;Ethyl 2-(p-chlorophenoxy)isobutyrate;Ethyl clofibrate;Ethyl p-chlorophenoxyisobutyrate;Ethyl a-(4-chlorophenoxy)-a-methylpropionate;Ethyl a-(4-chlorophenoxy)isobutyrate;Ethyl a-(p-chlorophenoxy)-a-methylpropionate;Ethyl a-(p-chlorophenoxy)isobutyrate;Hyclorate;ICI 28257;Lipavil;Lipavlon;Lipomid;Liprinal;Miscleron;Misclerone;NSC 79389;Neo-Atromid;Normet;Normolipol;Recolip;Regelan;Serotinex;Sklerepmexe;Sklero-Tablinene;Sklerolip;Skleromexe;Ticlobran;Xyduril;p-Chlorophenoxyisobutyric acid ethyl ester;
EINECS(EC#)211-277-4
Molecular FormulaC₁₂H₁₅ClO₃
Molecular Weight242.6987

Chemical Properties

AppearanceClear Colorless Oil
refractive index1.503
storage temp2-8°C

Safety Data

Hazard Xn:Harmful;
Risk R22;R40
Safety

Poison by intravenous route. Moderately toxic by ingestion and other routes. An experimental teratogen. Other experimental reproductive effects. Reduces plasma lipid levels. Human systemic effects by ingestion: muscle weakness, muscle spasms, and fever. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits toxic fumes of Cl^?.
?

Hazard Codes: Xn,N
Risk Statements:
22: ?Harmful if swallowed?
37: ?Irritating to the respiratory system
38: ?Irritating to the skin
40: ?Limited evidence of a carcinogenic effect
41: ?Risk of serious damage to eyes
51: ?Toxic to aquatic organisms
53: ?May cause long-term adverse effects in the aquatic environment
Safety Statements:
26: ?In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: ?Wear suitable protective clothing?
37: ?Wear suitable gloves
39: ?Wear eye/face protection
45: ?In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
61: ?Avoid release to the environment. Refer to special instructions safety data sheet

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
guinea pig	LD50	oral	1280mg/kg (1280mg/kg)	?	Drugs of the Future. Vol. 4, Pg. 140, 1979.
hamster	LD50	intraperitoneal	1260mg/kg (1260mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1816, 1981.
hamster	LD50	oral	2400mg/kg (2400mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1816, 1981.
mammal (species unspecified)	LD50	oral	3gm/kg (3000mg/kg)	?	Drugs of the Future. Vol. 4, Pg. 140, 1979.
man	TDLo	oral	1071ug/kg (1.071mg/kg)	BEHAVIORAL: TREMOR	Neurology. Vol. 37, Pg. 881, 1987.
man	TDLo	oral	171mg/kg/6D-I (171mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS MUSCULOSKELETAL: OTHER CHANGES	Israel Journal of Medical Sciences. Vol. 20, Pg. 1082, 1984.
man	TDLo	oral	4232mg/kg/57W (4232mg/kg)	BEHAVIORAL: MUSCLE WEAKNESS BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) MUSCULOSKELETAL: OTHER CHANGES	Japanese Journal of Medicine. Vol. 29, Pg. 545, 1990.
mouse	LD50	intraperitoneal	540mg/kg (540mg/kg)	?	Arzneimittel-Forschung. Drug Research. Vol. 31, Pg. 1816, 1981.
mouse	LD50	intravenous	> 500mg/kg (500mg/kg)	?	Drugs in Japan Vol. -, Pg. 341, 1990.
mouse	LD50	oral	1220mg/kg (1220mg/kg)	?	Chemical and Pharmaceutical Bulletin. Vol. 32, Pg. 1568, 1984.
mouse	LD50	unreported	1500mg/kg (1500mg/kg)	?	British UK Patent Application. Vol. #2041937,
rabbit	LD50	oral	1370mg/kg (1370mg/kg)	?	Drugs of the Future. Vol. 4, Pg. 140, 1979.
rat	LD50	intraperitoneal	910mg/kg (910mg/kg)	?	Journal Europeen de Toxicologie. Vol. 5, Pg. 239, 1972.
rat	LD50	oral	940mg/kg (940mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"	Archivos de Farmacologia y Toxicologia. Vol. 6, Pg. 255, 1980.
rat	LD50	unreported	1500mg/kg (1500mg/kg)	?	United States Patent Document. Vol. #4412998,
women	TDLo	oral	80mg/kg/2D-I (80mg/kg)	?	New England Journal of Medicine. Vol. 301, Pg. 1345, 1979.

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Propanoic acid,2-(4-chlorophenoxy)-2-methyl-, ethyl ester cas no:637-07-0

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