Aureomycin hydrochloride;Chlortetracycline hydrochloride cas no:64-72-2
Synonyms: 2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,monohydrochloride (8CI); 2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,monohydrochloride, (4S,4aS,5aS,6S,12aS)- (9CI); 2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,monohydrochloride, [4S-(4a,4aa,5aa,6b,12aa)]-; 7-Chlorotetracyclinehydrochloride; 7-Chlorotetracycline monohydrochloride; Aureociclina;Aureocycline; Aureomycin hydrochloride; Aureomycin monohydrochloride; Aureovit12C80; Aurofac 100; Biomycin hydrochloride; Chlortetracycline hydrochloride;Chlortetracyclinium chloride; Fermycin Soluble; Isphamycin; NSC 13252
NameAureomycin hydrochloride;Chlortetracycline hydrochloride
CAS64-72-2
Synonyms2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,monohydrochloride (8CI); 2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,monohydrochloride, (4S,4aS,5aS,6S,12aS)- (9CI); 2-Naphthacenecarboxamide,7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,monohydrochloride, [4S-(4a,4aa,5aa,6b,12aa)]-; 7-Chlorotetracyclinehydrochloride; 7-Chlorotetracycline monohydrochloride; Aureociclina;Aureocycline; Aureomycin hydrochloride; Aureomycin monohydrochloride; Aureovit12C80; Aurofac 100; Biomycin hydrochloride; Chlortetracycline hydrochloride;Chlortetracyclinium chloride; Fermycin Soluble; Isphamycin; NSC 13252
EINECS(EC#)200-591-7
Molecular FormulaC22H23ClN2O8?HCl
Molecular Weight515.35
Appearanceodorless yellow solid
storage temp2-8°C
Globally Harmonized System of Classification adn Labelling of Chemicals(GHS)
Hazardclass6.1
Hazard Xi
Risk 36/37/38
Safety
Risk Statements:? 36/37/38
36/37/38:?Chlortetracycline hydrochloride (64-72-2) is?irritating to eyes, respiratory system and skin?
Safety Statements:? 26-36
26:? In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36:? Wear suitable protective clothing?
WGK Germany:? 2
RTECS : QI7800000
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Organism
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Test Type
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Route
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Reported Dose (Normalized Dose)
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Effect
|
Source
|
|
cat
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LD
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intravenous
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> 50mg/kg (50mg/kg)
|
gastrointestinal: nausea or vomiting
|
Annals of the New York Academy of Sciences. Vol. 51, Pg. 182, 1948.
|
|
dog
|
LDLo
|
intravenous
|
150mg/kg (150mg/kg)
|
behavioral: tremor
lungs, thorax, or respiration: dyspnea
kidney, ureter, and bladder: hematuria
|
Annals of the New York Academy of Sciences. Vol. 51, Pg. 254, 1948.
|
|
guinea pig
|
LD
|
subcutaneous
|
> 300mg/kg (300mg/kg)
|
?
|
Annals of the New York Academy of Sciences. Vol. 51, Pg. 182, 1948.
|
|
guinea pig
|
LDLo
|
intravenous
|
100mg/kg (100mg/kg)
|
?
|
Annals of the New York Academy of Sciences. Vol. 51, Pg. 182, 1948.
|
|
mouse
|
LD50
|
intraperitoneal
|
197mg/kg (197mg/kg)
|
?
|
Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 278, 1970.
|
|
mouse
|
LD50
|
intravenous
|
100mg/kg (100mg/kg)
|
?
|
Arzneimittel-Forschung. Drug Research. Vol. 14, Pg. 95, 1964.
|
|
mouse
|
LD50
|
oral
|
2314mg/kg (2314mg/kg)
|
?
|
Arzneimittel-Forschung. Drug Research. Vol. 14, Pg. 95, 1964.
|
|
mouse
|
LDLo
|
subcutaneous
|
400mg/kg (400mg/kg)
|
?
|
Annals of the New York Academy of Sciences. Vol. 51, Pg. 182, 1948.
|
|
rabbit
|
LD
|
intravenous
|
> 50mg/kg (50mg/kg)
|
?
|
Annals of the New York Academy of Sciences. Vol. 51, Pg. 182, 1948.
|
|
rat
|
LD
|
oral
|
> 3gm/kg (3000mg/kg)
|
?
|
Annals of the New York Academy of Sciences. Vol. 51, Pg. 182, 1948.
|
|
rat
|
LD50
|
intraperitoneal
|
335mg/kg (335mg/kg)
|
behavioral: convulsions or effect on seizure threshold
lungs, thorax, or respiration: respiratory stimulation
|
Antibiotics Annual. Vol. 1, Pg. 63, 1953/1954.
|
|
rat
|
LD50
|
intravenous
|
100mg/kg (100mg/kg)
|
?
|
Bollettino Chimico Farmaceutico. Vol. 102, Pg. 660, 1963.
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