dog
|
LD50
|
intravenous
|
> 6gm/kg (6000mg/kg)
|
|
Drugs in Japan Vol. -, Pg. 565, 1990.
|
dog
|
LD50
|
oral
|
> 6gm/kg (6000mg/kg)
|
|
Drugs in Japan Vol. -, Pg. 661, 1995.
|
man
|
TDLo
|
intravenous
|
800mg/kg/4W-I (800mg/kg)
|
lungs, thorax, or respiration: other changes
|
Annals of Internal Medicine. Vol. 116, Pg. 522, 1992.
|
man
|
TDLo
|
intravenous
|
814mg/kg/18D- (814mg/kg)
|
kidney, ureter, and bladder: interstitial nephritis
skin and appendages (skin): "dermatitis, allergic: after systemic exposure"
|
American Journal of Kidney Diseases. Vol. 16, Pg. 259, 1990.
|
monkey
|
LD50
|
oral
|
> 6gm/kg (6000mg/kg)
|
|
Drugs in Japan Vol. -, Pg. 661, 1995.
|
mouse
|
LD50
|
intraperitoneal
|
8120mg/kg (8120mg/kg)
|
sense organs and special senses: ptosis: eye
behavioral: altered sleep time (including change in righting reflex)
behavioral: changes in motor activity (specific assay)
|
Chemotherapy Vol. 30(Suppl,
|
mouse
|
LD50
|
intravenous
|
4990mg/kg (4990mg/kg)
|
behavioral: tremor
behavioral: convulsions or effect on seizure threshold
lungs, thorax, or respiration: acute pulmonary edema
|
Chemotherapy Vol. 30(Suppl,
|
mouse
|
LD50
|
oral
|
> 10gm/kg (10000mg/kg)
|
|
Drugs in Japan Vol. -, Pg. 565, 1990.
|
mouse
|
LD50
|
subcutaneous
|
> 10gm/kg (10000mg/kg)
|
|
Drugs in Japan Vol. -, Pg. 565, 1990.
|
rabbit
|
LD50
|
intravenous
|
> 6gm/kg (6000mg/kg)
|
|
Drugs in Japan Vol. -, Pg. 565, 1990.
|
rat
|
LD50
|
intraperitoneal
|
8250mg/kg (8250mg/kg)
|
sense organs and special senses: ptosis: eye
behavioral: altered sleep time (including change in righting reflex
behavioral: changes in motor activity (specific assay)
|
Chemotherapy Vol. 30(Suppl,
|
rat
|
LD50
|
intravenous
|
6790mg/kg (6790mg/kg)
|
behavioral: tremor
behavioral: convulsions or effect on seizure threshold
lungs, thorax, or respiration: acute pulmonary edema
|
Chemotherapy Vol. 30(Suppl,
|
rat
|
LD50
|
oral
|
> 10gm/kg (10000mg/kg)
|
|
Drugs in Japan Vol. -, Pg. 565, 1990.
|
rat
|
LD50
|
subcutaneous
|
> 10gm/kg (10000mg/kg)
|
|
Drugs in Japan Vol. -, Pg. 565, 1990.
|