74356-00-6|5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[[4-(2-amino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl]carbonyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,sodium salt (1:2), (6R,7S)-Products Supply

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[[4-(2-amino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl]carbonyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,sodium salt (1:2), (6R,7S)- cas no:74356-00-6

Synonyms: Apatef;Cefotan;Cefotetan disodium;Cefotetan sodium;Ceftenon;Cepan Darvilen;YM 09330;Yamatetan;(6R,7S)-4-((2-Carboxy-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl)carbamoyl)-1,3-dithietane-D2,a-malonamic Acid Disodium Salt;(6R,7S)-7-(4-(Carbamoylcarboxymethylene)-1,3-dithietane-2-carboxamido)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Disodium Salt;

Identification

Name5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[[4-(2-amino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl]carbonyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,sodium salt (1:2), (6R,7S)-
CAS74356-00-6
SynonymsApatef;Cefotan;Cefotetan disodium;Cefotetan sodium;Ceftenon;Cepan Darvilen;YM 09330;Yamatetan;(6R,7S)-4-((2-Carboxy-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-7-yl)carbamoyl)-1,3-dithietane-D2,a-malonamic Acid Disodium Salt;(6R,7S)-7-(4-(Carbamoylcarboxymethylene)-1,3-dithietane-2-carboxamido)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Disodium Salt;
EINECS(EC#)277-834-9
Molecular FormulaC₁₇H₁₅N₇Na₂O₈S₄
Molecular Weight619.59

Safety Data

Hazard Xn
Risk R20/21/22
Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
20/21/22: Disodium (7R)-7-[[4-(carbamoyl-carboxylato-methylidene)-1,3-dithietane-2-carbonyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate (74356-00-6) is harmful by inhalation, in contact with skin and if swallowed
36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 26-36
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing

Toxicity

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intravenous	> 6gm/kg (6000mg/kg)		Drugs in Japan Vol. -, Pg. 565, 1990.
dog	LD50	oral	> 6gm/kg (6000mg/kg)		Drugs in Japan Vol. -, Pg. 661, 1995.
man	TDLo	intravenous	800mg/kg/4W-I (800mg/kg)	lungs, thorax, or respiration: other changes	Annals of Internal Medicine. Vol. 116, Pg. 522, 1992.
man	TDLo	intravenous	814mg/kg/18D- (814mg/kg)	kidney, ureter, and bladder: interstitial nephritis skin and appendages (skin): "dermatitis, allergic: after systemic exposure"	American Journal of Kidney Diseases. Vol. 16, Pg. 259, 1990.
monkey	LD50	oral	> 6gm/kg (6000mg/kg)		Drugs in Japan Vol. -, Pg. 661, 1995.
mouse	LD50	intraperitoneal	8120mg/kg (8120mg/kg)	sense organs and special senses: ptosis: eye behavioral: altered sleep time (including change in righting reflex) behavioral: changes in motor activity (specific assay)	Chemotherapy Vol. 30(Suppl,
mouse	LD50	intravenous	4990mg/kg (4990mg/kg)	behavioral: tremor behavioral: convulsions or effect on seizure threshold lungs, thorax, or respiration: acute pulmonary edema	Chemotherapy Vol. 30(Suppl,
mouse	LD50	oral	> 10gm/kg (10000mg/kg)		Drugs in Japan Vol. -, Pg. 565, 1990.
mouse	LD50	subcutaneous	> 10gm/kg (10000mg/kg)		Drugs in Japan Vol. -, Pg. 565, 1990.
rabbit	LD50	intravenous	> 6gm/kg (6000mg/kg)		Drugs in Japan Vol. -, Pg. 565, 1990.
rat	LD50	intraperitoneal	8250mg/kg (8250mg/kg)	sense organs and special senses: ptosis: eye behavioral: altered sleep time (including change in righting reflex behavioral: changes in motor activity (specific assay)	Chemotherapy Vol. 30(Suppl,
rat	LD50	intravenous	6790mg/kg (6790mg/kg)	behavioral: tremor behavioral: convulsions or effect on seizure threshold lungs, thorax, or respiration: acute pulmonary edema	Chemotherapy Vol. 30(Suppl,
rat	LD50	oral	> 10gm/kg (10000mg/kg)		Drugs in Japan Vol. -, Pg. 565, 1990.
rat	LD50	subcutaneous	> 10gm/kg (10000mg/kg)		Drugs in Japan Vol. -, Pg. 565, 1990.

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Hangzhou Pharmsun Pharmaceutical Ltd.: Tel:+86-(571)-2886-1623; Address: Room 606, Xihu Mansion, 202 Wen Er Road, Hangzhou 310012,

Sinotau International Co. Ltd.: Tel:+86-(10)-84926864; Address: 4th Area No. 5 Courtyard Anwaibeiyuan, Chaoyang District, Beijing 100012,

Facus Pharmaceutical Co., Ltd.: Tel:+86-(574)-6237-8411; Address: 24Fl, Yuanjing Building, Beilun, Ningbo, Zhejiang 315800,

Taizhou Xingcheng Chempharm Co., Ltd.: Tel:+86-(576)-88886292, 88525005; Address: B Area. 10 Floor.Yaodadasha. 289#.Shifu Road, Taizhou, Zhejiang 318000,

Manus Aktteva: Tel:+91-(79)-65123395; Address: 303, 3rd Floor, Royale Manor, Law Garden, Dhulia Kot Road, Ellisbridge, Ahmedabad, Gujarat 380006,

Guangdong Evergreen pharmaceutical Co.,Ltd: Tel:+86-22-58812056; Address: Rm A-1-1002,Yunlang Xinju,No.149Weijin Road,Heping Distr.300070China

AOPHARM: Tel:86-311-66600578; Address: C-2103 Wonder Business Square, 15 Yuhua West Rd.

HEBEI CUI FENG IMPORT&EXPORT TRADE CO.,LTD: Tel:86-311-80955068; Address: No 98 Gongnong Street,Shijiazhuang Hebei,China

Boc Sciences: Tel:1-631-5046093; Address: 45-16 Ramsey Road, Shirley, NY 11967, USA

Shanghai Forever Synthesis Co.,Ltd.: Tel:86-21-61124658; Address: Nianjiabang Rd, Pudong, Shanghai

Hui Chem Company Limited: Tel:86-21-60542966; Address: Lane 299 Bisheng Rd,Pudong District

Shanghai Forever Synthesis Co.,Ltd.: Tel:86-21-61124658; Address: Nianjiabang Rd, Pudong, Shanghai

Shijiazhuang Sdyano Fine Chemical Co., Ltd: Tel:86-311-80800737; Address: Room 37-2-2501, Yiyuan Dong Gang Jianshe Nan Stree

Jinlan Pharm-Drugs Technology Co., Limited: Tel:86-571-85829152; Address: Room 606, Fuyi Center, #298 Quanfuqiao Road, Jiang

Nanjing Norris-Pharm Technology Co., Ltd.: Tel:86-25-66112885; Address: 2rd Qiande Road Jiangning Life&Science Park Nanjin

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[[4-(2-amino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl]carbonyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,sodium salt (1:2), (6R,7S)- cas no:74356-00-6

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